Title:
BASE EDITORS WITH IMPROVED PRECISION AND SPECIFICITY
Document Type and Number:
WIPO Patent Application WO/2018/218188
Kind Code:
A3
Abstract:
Methods and compositions for improving the genome-wide specificities of targeted base editing technologies.
Inventors:
JOUNG J KEITH (US)
GEHRKE JASON MICHAEL (US)
GEHRKE JASON MICHAEL (US)
Application Number:
PCT/US2018/034719
Publication Date:
January 03, 2019
Filing Date:
May 25, 2018
Export Citation:
Assignee:
MASSACHUSETTS GEN HOSPITAL (US)
International Classes:
C12N15/00; C07K14/00; C12N9/22; C12N9/78
Foreign References:
| US20170121693A1 | 2017-05-04 |
Other References:
RATHORE A. ET AL.: "The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution", J MOL BIOL, vol. 425, no. 22, 15 November 2013 (2013-11-15), pages 4442 - 4454, XP028751723
Attorney, Agent or Firm:
DEYOUNG, Janice Kugler et al. (US)
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