Title:
BCMA-TARGETED CHIMERIC ANTIGEN RECEPTOR BASED ON FULLY HUMAN AND MOUSE SINGLE-CHAIN ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016576
Kind Code:
A1
Abstract:
A BCMA-targeted single-chain antibody and a chimeric antigen receptor based thereon and an applications thereof. Provided is a fully human and mouse single-chain antibody that specifically bind to a BCMA. The chimeric antigen receptor comprises an anti-BCMA fully human or mouse single-chain antibody, a human CD8α hinge region, a human CD8α transmembrane region, a human 41BB intracellular region and a human CD3ζ intracellular region which are sequentially connected. Furthermore, provided is a CAR-T cell based on the anti-BCMA fully human or mouse single-chain antibody, which may specifically bind to the BCMA and effectively kill malignant tumor cells of a B lymphocyte cell line expressing BCMA.
Inventors:
HUANG FEI (CN)
Application Number:
PCT/CN2022/117508
Publication Date:
February 16, 2023
Filing Date:
September 07, 2022
Export Citation:
Assignee:
HRAIN BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; C12N5/10; C12N7/01; C12N15/62; C12N15/867
Domestic Patent References:
| WO2021031113A1 | 2021-02-25 | |||
| WO2020236795A2 | 2020-11-26 | |||
| WO2020073917A1 | 2020-04-16 |
Foreign References:
| CN109485733A | 2019-03-19 | |||
| CN112062851A | 2020-12-11 | |||
| CN108004259A | 2018-05-08 | |||
| CN109320615A | 2019-02-12 | |||
| CN108395478A | 2018-08-14 |
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