Title:
BCMA-TARGETING ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/133877
Kind Code:
A1
Abstract:
Provided in the present invention are a specific antibody of BCMA and a BCMA-targeting immune effector cell, and also provided are a chimeric antigen receptor-modified T cell prepared using the antibody and the use thereof.
Inventors:
WANG PENG (CN)
WANG HUAMAO (CN)
JIANG HUA (CN)
WANG HUAMAO (CN)
JIANG HUA (CN)
Application Number:
PCT/CN2018/073863
Publication Date:
July 26, 2018
Filing Date:
January 23, 2018
Export Citation:
Assignee:
CARSGEN THERAPEUTICS CO LTD (CN)
International Classes:
A61K35/17; C07K16/28; A61K39/395; A61P35/00; C07K19/00; C12N5/10; C12N7/01; C12N15/13; C12N15/63; G01N33/574; G01N33/68
Domestic Patent References:
| WO2016090327A2 | 2016-06-09 | |||
| WO1994013804A1 | 1994-06-23 |
Foreign References:
| CN104968683A | 2015-10-07 | |||
| CN104968682A | 2015-10-07 | |||
| CN103562225A | 2014-02-05 | |||
| CN105143263A | 2015-12-09 | |||
| CN105777911A | 2016-07-20 | |||
| US9209965W | 1992-11-20 |
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GERTZ ET AL., BLOOD, vol. 106, no. 8, 2005, pages 2837 - 2840
FACON ET AL., BLOOD, vol. 97, no. 6, 2001, pages 1566 - 1571
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HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
TOMLINSON ET AL., METHODS ENZYMOL., vol. 326, 2000, pages 461 - 479
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
COLOMAMORRISON, NATURE BIOTECHNOLOGY, vol. 15, 1997, pages 159 - 163
KABAT ET AL.: "sequences of proteins of immunological interest", 1991, UNITED STATES PUBLIC HEALTH SERVICE
EDELMAN ET AL., BIOCHEMISTRY, vol. 63, 1969, pages 78 - 85
CUESTA ET AL.: "Multivalent antibodies: when design surpasses evolution", TRENDS IN BIOTECHNOLOGY, vol. 28, 2010, pages 355 - 362, XP002666460, doi:10.1016/j.tibtech.2010.03.007
J. SAMBROOK ET AL.: "Molecular Cloning Experimental Guide", 2002, SCIENCE PRESS
See also references of EP 3572427A4
GERTZ ET AL., BLOOD, vol. 106, no. 8, 2005, pages 2837 - 2840
FACON ET AL., BLOOD, vol. 97, no. 6, 2001, pages 1566 - 1571
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
TOMLINSON ET AL., METHODS ENZYMOL., vol. 326, 2000, pages 461 - 479
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
COLOMAMORRISON, NATURE BIOTECHNOLOGY, vol. 15, 1997, pages 159 - 163
KABAT ET AL.: "sequences of proteins of immunological interest", 1991, UNITED STATES PUBLIC HEALTH SERVICE
EDELMAN ET AL., BIOCHEMISTRY, vol. 63, 1969, pages 78 - 85
CUESTA ET AL.: "Multivalent antibodies: when design surpasses evolution", TRENDS IN BIOTECHNOLOGY, vol. 28, 2010, pages 355 - 362, XP002666460, doi:10.1016/j.tibtech.2010.03.007
J. SAMBROOK ET AL.: "Molecular Cloning Experimental Guide", 2002, SCIENCE PRESS
See also references of EP 3572427A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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