BCMA-TARGETING CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF

WIPO Patent Application WO/2023/088359

A1

Provided in the present invention is a BCMA-targeting chimeric antigen receptor, comprising an extracellular antigen recognition domain, a hinge region, a transmembrane region and an intracellular domain. The extracellular antigen recognition domain comprises an anti-BCMA scFv antibody. The amino acid sequences of VH complementarity determining regions CDR1, CDR2 and CDR3 of the scFv antibody respectively comprise amino acid sequences as shown in SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. The amino acid sequences of VL complementarity determining regions CDR1, CDR2 and CDR3 of the scFv antibody respectively comprise amino acid sequences as shown in SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6.

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BAI DAYONG (CN)
ZHANG YUNLONG (CN)
ZHANG CHAO (CN)
LV LULU (CN)
ZHOU LI (CN)
WANG YONGZENG (CN)
WANG RUI (CN)
DING WEI (CN)
LU JIAXING (CN)
ZHANG QIMENG (CN)

PCT/CN2022/132545

May 25, 2023

November 17, 2022

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JUVENTAS CELL THERAPY LTD (CN)

C07K19/00; A61K39/00; A61P35/00; C12N5/10; C12N15/62; C12N15/867

CN109021116A	2018-12-18
CN110041433A	2019-07-23
CN113185615A	2021-07-30
CN111944053A	2020-11-17
CN111944054A	2020-11-17
CN112437671A	2021-03-02
CN105940014A	2016-09-14

PEKSUNG INTELLECTUAL PROPERTY LTD. (CN)

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