BENZAMIDE DERIVATIVE OR SALT THEREOF - YAMANOUCHI PHARMA CO LTD

Title:

BENZAMIDE DERIVATIVE OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2004/110986

Kind Code:

A1

Abstract:

A compound which functions to inhibit capsaicin receptor VR1 activation and is useful as a therapeutic agent for, e.g., various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, and bladder diseases including overactive bladder. It is a benzamide derivative or salt thereof, the derivative being characterized by comprising: a benzene ring; a ring D (a mono- or dicyclic hydrocarbon ring or mono- or dicyclic heteroaromatic ring) bonded to the benzene ring through an amide bond; a ring E (a mono- or dicyclic hydrocarbon ring or mono- or dicyclic heteroaromatic ring) directly bonded to the benzene ring; and A (an amino moiety or a mono- or dicyclic heteroring) bonded to the benzene ring through L (a lower alkylene).

Inventors:

KURAMOCHI TAKAHIRO (JP)
ASAI NORIO (JP)
IKEGAI KAZUHIRO (JP)
AKAMATSU SEIJIRO (JP)
HARADA HIRONORI (JP)
ISHIKAWA NORIKO (JP)
SHIRAKAMI SHOHEI (JP)
MIYAMOTO SATOSHI (JP)
WATANABE TOSHIHIRO (JP)
KISO TETSUO (JP)

Application Number:

PCT/JP2004/008479

Publication Date:

December 23, 2004

Filing Date:

June 10, 2004

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
KURAMOCHI TAKAHIRO (JP)
ASAI NORIO (JP)
IKEGAI KAZUHIRO (JP)
AKAMATSU SEIJIRO (JP)
HARADA HIRONORI (JP)
ISHIKAWA NORIKO (JP)
SHIRAKAMI SHOHEI (JP)
MIYAMOTO SATOSHI (JP)
WATANABE TOSHIHIRO (JP)
KISO TETSUO (JP)

International Classes:

A61K31/167; A61K31/428; A61K31/4453; A61K31/454; A61K31/4709; A61K31/4725; A61K31/496; A61K31/5377; A61K31/538; A61K31/55; A61P1/04; A61P11/00; A61P11/06; A61P13/10; A61P17/04; A61P25/06; A61P29/00; C07C237/40; C07D209/08; C07D209/34; C07D209/36; C07D213/75; C07D215/38; C07D217/04; C07D223/16; C07D231/56; C07D235/06; C07D241/42; C07D249/18; C07D263/58; C07D265/36; C07D277/62; C07D277/64; C07D277/82; C07D279/16; C07D295/155; C07D307/79; C07D317/64; C07D317/66; C07D333/54; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D417/14; C07D471/04; (IPC1-7): C07C237/40; A61K31/167; A61K31/428; A61K31/4453; A61K31/454; A61K31/4709; A61K31/4725; A61K31/496; A61K31/5377; A61K31/538; A61K31/55; A61P1/04; A61P11/00; A61P11/06; A61P13/10; A61P17/04; A61P25/06; A61P29/00; C07D215/38; C07D217/22; C07D263/58; C07D265/36; C07D277/68; C07D295/14; C07D417/12

Domestic Patent References:

WO2003055848A2	2003-07-10
WO2003068749A1	2003-08-21
WO2002008221A2	2002-01-31

Foreign References:

JP2003055209A	2003-02-26
JP2002003370A	2002-01-09

Other References: