Title:
BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS
Document Type and Number:
WIPO Patent Application WO/2012/061418
Kind Code:
A3
Abstract:
The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
Inventors:
JIA ZHAOZHONG J (US)
SONG YONGHONG (US)
XU QING (US)
KANE BRIAN (US)
BAUER SHAWN M (US)
PANDEY ANJALI (US)
SONG YONGHONG (US)
XU QING (US)
KANE BRIAN (US)
BAUER SHAWN M (US)
PANDEY ANJALI (US)
Application Number:
PCT/US2011/058826
Publication Date:
August 02, 2012
Filing Date:
November 01, 2011
Export Citation:
Assignee:
PORTOLA PHARM INC (US)
JIA ZHAOZHONG J (US)
SONG YONGHONG (US)
XU QING (US)
KANE BRIAN (US)
BAUER SHAWN M (US)
PANDEY ANJALI (US)
JIA ZHAOZHONG J (US)
SONG YONGHONG (US)
XU QING (US)
KANE BRIAN (US)
BAUER SHAWN M (US)
PANDEY ANJALI (US)
International Classes:
A61K31/455; C07D213/82; A61P35/00; C07D401/04; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D495/04
Domestic Patent References:
| WO2009136995A2 | 2009-11-12 | |||
| WO2000076980A1 | 2000-12-21 | |||
| WO2005009443A1 | 2005-02-03 |
Foreign References:
| EP1184376A1 | 2002-03-06 | |||
| US20060217417A1 | 2006-09-28 |
Attorney, Agent or Firm:
HOPKINS, Mark, H. et al. (Two Embarcadero Center Eighth Floo, San Francisco California, US)
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