Title:
BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS
Document Type and Number:
WIPO Patent Application WO/2006/046593
Kind Code:
A1
Abstract:
Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, OH, alkoxy, optionally substituted amino or the like; R3 represents an H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno or the like; R4 and R5 respectively represent an H, optionally substituted alkyl, halogeno or the like; R6 and R7 respectively represent an H or alkyl; R8 represents a -X2R10 [wherein R10 represents a -COR11 (wherein R11 represents an OH, optionally substituted alkoxy, optionally substituted amino or the like), -SO2R12 (wherein R12 represents an optionally substituted alkyl, optionally substituted amino or the like), tetrazole-5-yl or the like; and X2 represents a single bond, optionally substituted alkylene or the like]; X1 represents an -NH-, -O-, -S- or the like; Y1 represents an optionally substituted phenyl or optionally substituted 5-membered or 6-membered aromatic heterocyclyl; and Y2 represents an optionally substituted aryl, substituted heterocyclyl or the like.]
Inventors:
TAMAKI KAZUHIKO
YAMAGUCHI TAKAHIRO
ODA KOZO
TERASAKA NAOKI
NAKAI DAISUKE
NAKADAI MASAKAZU
YAMAGUCHI TAKAHIRO
ODA KOZO
TERASAKA NAOKI
NAKAI DAISUKE
NAKADAI MASAKAZU
Application Number:
PCT/JP2005/019676
Publication Date:
May 04, 2006
Filing Date:
October 26, 2005
Export Citation:
Assignee:
SANKYO CO (JP)
TAMAKI KAZUHIKO
YAMAGUCHI TAKAHIRO
ODA KOZO
TERASAKA NAOKI
NAKAI DAISUKE
NAKADAI MASAKAZU
TAMAKI KAZUHIKO
YAMAGUCHI TAKAHIRO
ODA KOZO
TERASAKA NAOKI
NAKAI DAISUKE
NAKADAI MASAKAZU
International Classes:
C07C65/24; A61K31/192; A61K31/216; A61K31/24; A61K31/343; A61K31/381; A61K31/41; A61K31/425; A61K31/4418; A61K31/455; A61K31/506; C07C65/26; C07C65/28; C07C65/30; C07C65/34; C07C65/40; C07C205/35; C07C217/80; C07C235/34; C07C235/46; C07C255/57; C07C311/04; C07C311/08; C07C311/25; C07C317/06; C07C317/22; C07C317/46; C07D213/55; C07D213/65; C07D213/71; C07D213/79; C07D213/80; C07D239/26; C07D257/04; C07D277/30; C07D307/84; C07D333/24
Domestic Patent References:
| WO2004007464A1 | 2004-01-22 | |||
| WO2003048140A1 | 2003-06-12 | |||
| WO2005077124A2 | 2005-08-25 |
Other References:
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC.
See also references of EP 1806332A4
See also references of EP 1806332A4
Attorney, Agent or Firm:
Yaguchi, Toshiaki c/o SANKYO COMPANY (LIMITED 2-58, Hiromachi 1-chome, Shinagawa-k, Tokyo 10, JP)
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