Title:
BENZENE COMPOUND AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1996/006068
Kind Code:
A1
Abstract:
A benzene compound represented by general formula (I) (wherein each symbol is as defined in the specification), an optical isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjoegren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma, and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
Inventors:
FUJITA TETSURO (JP)
ADACHI KUNITOMO (JP)
KOHARA TOSHIYUKI (JP)
KIUCHI MASATOSHI (JP)
CHIBA KENJI (JP)
TESHIMA KOJI (JP)
MISHINA TADASHI (JP)
ADACHI KUNITOMO (JP)
KOHARA TOSHIYUKI (JP)
KIUCHI MASATOSHI (JP)
CHIBA KENJI (JP)
TESHIMA KOJI (JP)
MISHINA TADASHI (JP)
Application Number:
PCT/JP1995/001654
Publication Date:
February 29, 1996
Filing Date:
August 22, 1995
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
FUJITA TETSURO (JP)
ADACHI KUNITOMO (JP)
KOHARA TOSHIYUKI (JP)
KIUCHI MASATOSHI (JP)
CHIBA KENJI (JP)
TESHIMA KOJI (JP)
MISHINA TADASHI (JP)
FUJITA TETSURO (JP)
ADACHI KUNITOMO (JP)
KOHARA TOSHIYUKI (JP)
KIUCHI MASATOSHI (JP)
CHIBA KENJI (JP)
TESHIMA KOJI (JP)
MISHINA TADASHI (JP)
International Classes:
C07C215/28; C07C215/30; C07C215/56; C07C217/64; C07C217/72; C07C219/22; C07C225/16; C07C233/18; C07C233/31; C07C233/36; C07C233/73; C07C271/16; C07C271/18; (IPC1-7): C07C215/28; C07C217/64; C07C233/18; C07C233/73; C07C271/16; A61K31/135
Foreign References:
| JPS5615250A | 1981-02-14 | |||
| JPS57128660A | 1982-08-10 | |||
| JPS58118596A | 1983-07-14 | |||
| JPS58105946A | 1983-06-24 | |||
| JPS5944345A | 1984-03-12 | |||
| JPS5959651A | 1984-04-05 | |||
| JPS61155375A | 1986-07-15 | |||
| US4634689A | 1987-01-06 | |||
| US4667038A | 1987-05-19 | |||
| JPS63139179A | 1988-06-10 | |||
| JPS63258837A | 1988-10-26 | |||
| JPH0285268A | 1990-03-26 | |||
| JPH02264749A | 1990-10-29 | |||
| US5039706A | 1991-08-13 | |||
| JPH04275276A | 1992-09-30 | |||
| JPH05163221A | 1993-06-29 | |||
| JPH05201936A | 1993-08-10 | |||
| GB1134687A | 1968-11-27 |
Other References:
See also references of EP 0778263A4
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