BENZENE DERIVATIVE USEFUL FOR ISCHEMIC DISEASES

Title:

BENZENE DERIVATIVE USEFUL FOR ISCHEMIC DISEASES

Document Type and Number:

WIPO Patent Application WO/1995/000471

Kind Code:

A1

Abstract:

A compound represented by general formula (I) or a possible stereoisomer or optical isomer thereof, and a pharmaceutically acceptable salt thereof (wherein R1, R2, R3 and R4 represent each hydrogen, etc.; R6 and R7 represent each optionally substituted lower alkyl, etc.; A represents a group represented by general formula (II), etc. wherein R5 represents hydrogen, etc.; and n represents an integer of 2 to 6). The compound (I) has not only a vasorelaxation activity (calcium antagonism) and a lipid peroxide inhibitor activity but also a calcium overload inhibitor activity, and is useful as a preventive or remedy for ischemic diseases and as a hypotensive.

Inventors:

OHI NOBUHIRO (JP)
KATO TATSUYA (JP)
OZAKI TOMOKAZU (JP)

Application Number:

PCT/JP1994/001009

Publication Date:

January 05, 1995

Filing Date:

June 23, 1994

Export Citation:

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)
OHI NOBUHIRO (JP)
KATO TATSUYA (JP)
OZAKI TOMOKAZU (JP)

International Classes:

A61K31/4164; A61K31/42; A61K31/425; A61P9/12; C07C235/50; C07C261/04; C07C311/18; C07D233/64; C07D249/08; C07D277/10; C07C233/78; C07D277/14; C07D277/82; C07D285/22; C07D317/64; C07D405/12; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D417/14; C07D419/12; C07D513/10; (IPC1-7): C07C233/78; C07C235/50; C07C261/04; C07C311/18; C07C311/29; C07C327/48; C07D233/64; C07D249/08; C07D271/06

Foreign References:

JPS57181053A	1982-11-08
JPS6242977A	1987-02-24
JPS63313757A	1988-12-21
EP0211670B1	1990-05-09

Other References: