Title:
BENZENE RING COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/127923
Kind Code:
A1
Abstract:
The present invention relates to a benzene ring compound and a use thereof. In particular, provided is a compound as shown in formula I, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof. The present compound has good therapeutic effects on tumors.
Inventors:
SHI YUFENG (CN)
MA WENJIANG (CN)
MA WENJIANG (CN)
Application Number:
PCT/CN2021/139355
Publication Date:
June 23, 2022
Filing Date:
December 17, 2021
Export Citation:
Assignee:
NANJING SHIJIANG MEDICINE TECH CO LTD (CN)
International Classes:
C07D471/04; A61P35/00; A61P35/02; C07C237/40; C07D213/70; C07D213/75; C07D233/60; C07D239/42; C07D277/42; C07D401/04; C07D401/06; C12Q1/02; C12Q1/6886
Domestic Patent References:
| WO2011161256A1 | 2011-12-29 | |||
| WO2010151799A2 | 2010-12-29 |
Other References:
NURMAGANBETOV ZH. S., SHULTZ E. E., CHERNOV S. V., TURMUKHAMBETOV A. ZH., SEYDAKHMETOVA R. B., SHAKIROV M. M., TOLSTIKOV G. A., AD: "Synthesis of substituted indolizino[8,7-b]indoles from harmine and their biological activity", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, SPRINGER US, NEW YORK, vol. 46, no. 12, 1 March 2011 (2011-03-01), New York , pages 1494 - 1499, XP055943279, ISSN: 0009-3122, DOI: 10.1007/s10593-011-0698-z
VENKATARAMANA REDDY P.O., MISHRA SHRIPRADA, TANTAK MUKUND P., NIKHIL KUMAR, SADANA RACHNA, SHAH KAVITA, KUMAR DALIP: "Design, synthesis and in vitro cytotoxicity studies of novel β -carbolinium bromides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 6, 1 March 2017 (2017-03-01), AMSTERDAM, NL , pages 1379 - 1384, XP055943280, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.02.010
TRUITT PRICE, ET AL. : "Amebicides. I. Some 1-(1, 4-Dihydro-1, 4-Dioxo-3-Hydroxy-2-Naphthyl)-Pyridinium Betaines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 25, 30 June 1960 (1960-06-30), AMSTERDAM, NL , pages 962 - 964, XP055943282, ISSN: 0960-894X
"UniProtKB", Database accession no. P40261
VENKATARAMANA REDDY P.O., MISHRA SHRIPRADA, TANTAK MUKUND P., NIKHIL KUMAR, SADANA RACHNA, SHAH KAVITA, KUMAR DALIP: "Design, synthesis and in vitro cytotoxicity studies of novel β -carbolinium bromides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 6, 1 March 2017 (2017-03-01), AMSTERDAM, NL , pages 1379 - 1384, XP055943280, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.02.010
TRUITT PRICE, ET AL. : "Amebicides. I. Some 1-(1, 4-Dihydro-1, 4-Dioxo-3-Hydroxy-2-Naphthyl)-Pyridinium Betaines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 25, 30 June 1960 (1960-06-30), AMSTERDAM, NL , pages 962 - 964, XP055943282, ISSN: 0960-894X
"UniProtKB", Database accession no. P40261
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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