Title:
BENZENE SULFONAMIDE IDO1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/161892
Kind Code:
A1
Abstract:
A benzene sulfonamide compound having structural features of formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and use thereof as an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. Experimental results indicate that the compound has a significant inhibitory effect on activities of IDO1, and can effectively promote the proliferation of T cells, inhibit the differentiation of naïve T cells into regulatory T cells, and reverse IDO1-mediated immunosuppression, being able to be used in the treatment of related diseases having pathological features of IDO1-mediated kynurenine metabolic pathways, including cancers, viral infections, neurodegenerative diseases, cataracts, organ transplant rejection, depression, autoimmune diseases and the like.
Inventors:
LAI YISHENG (CN)
GE SHUSHAN (CN)
ZHENG YINGBO (CN)
ZOU YI (CN)
WANG FANG (CN)
XU QIANG (CN)
GUO WENJIE (CN)
WANG YAN (CN)
HU YUE (CN)
GE SHUSHAN (CN)
ZHENG YINGBO (CN)
ZOU YI (CN)
WANG FANG (CN)
XU QIANG (CN)
GUO WENJIE (CN)
WANG YAN (CN)
HU YUE (CN)
Application Number:
PCT/CN2018/078136
Publication Date:
September 13, 2018
Filing Date:
March 06, 2018
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
UNIV NANJING (CN)
UNIV NANJING (CN)
International Classes:
C07C311/46; A61K31/18; A61K31/63; A61P25/28; A61P31/12; A61P35/00; C07C303/38; C07C311/16; C07C311/17; C07C311/19; C07C311/39
Foreign References:
| CN106928101A | 2017-07-07 | |||
| CN101817767A | 2010-09-01 | |||
| CN103193691A | 2013-07-10 |
Other References:
MCCARROLL ANDREW J.: "Quinols As Novel Therapeutic Agents. 7.1 Synthesis of Antitumor 4-[1-(Arylsulfonyl-lH-indol-2-yl)]-4-hydroxycyclohe- xa-2, 5-dien-l-ones by Sonogashira Reactions", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 7, 8 March 2007 (2007-03-08), pages 1707 - 1710, XP055605876, ISSN: 1520-4804
MIRIAN MINA F.: "Synthesis and Cytotoxic Evaluation of Some Novel Sulfonamide Derivatives Against a Few Human Cancer Cells", IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 10, no. 4, 31 December 2011 (2011-12-31), pages 741 - 748, XP055605879, ISSN: 1735-0328
MIRIAN MINA F.: "Synthesis and Cytotoxic Evaluation of Some Novel Sulfonamide Derivatives Against a Few Human Cancer Cells", IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 10, no. 4, 31 December 2011 (2011-12-31), pages 741 - 748, XP055605879, ISSN: 1735-0328
Attorney, Agent or Firm:
BEIJING TINGLI PATENT FIRM(ORDINARY PARTNERSHIP) (CN)
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