Title:
BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS
Document Type and Number:
WIPO Patent Application WO2002020464
Kind Code:
A8
Abstract:
The present invention relates to trimesic acid amides, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, and processes for their preparation. Specifically, this invention relates to means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that active the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, as well as processes for preparation of the compounds. As such, the invention also concerns methods or uses of the compounds for the treatment of animals with hyperglycemia, especially for the treatment of type 2 diabetes.
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Inventors:
ROBINSON LOUISE (US)
CAIRNS NICHOLAS (US)
MANCHEM PRASAD V V S V (US)
SCHOW STEVEN R (US)
CAIRNS NICHOLAS (US)
MANCHEM PRASAD V V S V (US)
SCHOW STEVEN R (US)
Application Number:
PCT/US2001/028084
Publication Date:
July 10, 2003
Filing Date:
September 06, 2001
Export Citation:
Assignee:
TELIK INC (US)
ROBINSON LOUISE (US)
CAIRNS NICHOLAS (US)
MANCHEM PRASAD V V S V (US)
SCHOW STEVEN R (US)
ROBINSON LOUISE (US)
CAIRNS NICHOLAS (US)
MANCHEM PRASAD V V S V (US)
SCHOW STEVEN R (US)
International Classes:
A61K31/185; A61K31/192; A61K31/195; A61K31/245; A61P3/10; C07B61/00; C07C231/02; A61K38/28; C07C231/12; C07C233/81; C07C235/84; C07C303/22; C07C309/28; C07C309/51; G01N33/50; G01N33/566; (IPC1-7): C07C235/84; C07C309/28; C07C231/02; C07C231/12; C07C303/22; A61K31/185; G01N33/50
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