Title:
BENZENEDICARBOXYLIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2001092273
Kind Code:
A3
Abstract:
New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF- beta activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
Inventors:
JACKSON PAUL F
TSUKAMOTO TAKASHI
SLUSHER BARBARA S
WANG ERIC
TSUKAMOTO TAKASHI
SLUSHER BARBARA S
WANG ERIC
Application Number:
PCT/US2001/017309
Publication Date:
July 25, 2002
Filing Date:
May 29, 2001
Export Citation:
Assignee:
GUILFORD PHARM INC (US)
International Classes:
A61P13/08; A61P21/00; A61P27/06; C07C63/307; C07C63/68; C07C65/05; C07C65/40; C07C229/38; C07C229/60; C07C235/80; C07C259/06; C07C259/10; C07C317/44; C07C323/12; C07C323/56; C07C323/62; C07D231/06; C07D307/52; C07F9/38; (IPC1-7): C07C317/44; C07C63/307; C07C321/30; C07C205/60; C07C63/30; C07C229/60; C07C381/04; C07C63/26; C07C229/28; C07C205/57; C07C65/40; C07C233/64; C07C323/00; C07C65/05; C07C321/20; C07C237/06; C07C311/21; C07F9/38; A61K31/10; A61K31/185; A61K31/415; A61P21/00; A61P13/08; A61P27/06
Domestic Patent References:
| WO1998053812A1 | 1998-12-03 |
Foreign References:
| NL6606892A | 1966-07-25 | |||
| US4250182A | 1981-02-10 | |||
| EP0745673A2 | 1996-12-04 |
Other References:
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DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; EL-MAGHRABY, A. A. ET AL: "Synthesis of some new sulfonamides, arylsulfonates, saccharin derivatives from toluic acids", XP002188850, retrieved from STN Database accession no. 105:190584 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KUDLACEK, VLADIMIR ET AL: "5-(4-Carboxyphenoxy)isophthalic acid", XP002188851, retrieved from STN Database accession no. 85:177080 CA
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