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Title:
BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE
Document Type and Number:
WIPO Patent Application WO/2015/171558
Kind Code:
A3
Abstract:
The invention provides benzenesulfonamido and related compounds, pharmaceutical compositions, methods of promoting RORγ activity, increasing the amount of IL-17 in a subject, and treating cancer using such benzenesulfonamido and related compounds.

Inventors:
AICHER, Thomas Daniel (514 Burswood Court, Ann Arbor, MI, 48103, US)
SKALITZKY, Donald J. (7203 Warner Road, Saline, MI, 48176, US)
TAYLOR, Clarke B. (447 Manor Drive, Ann Arbor, MI, 48105, US)
VAN HUIS, Chad A. (13850 Plover Drive, Hartland, MI, 48353, US)
Application Number:
US2015/029167
Publication Date:
July 20, 2017
Filing Date:
May 05, 2015
Export Citation:
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Assignee:
LYCERA CORPORATION (2800 Plymouth Road, NCRC Building 2, Ann Arbor MI, 48109, US)
International Classes:
C07C311/21; A61K31/10; A61K31/18; A61K31/351; A61K31/402; A61K31/404; A61K31/415; A61K31/421; A61P31/00; A61P35/00; A61P37/04; C07C317/18; C07D207/09; C07D209/14; C07D231/28; C07D263/58; C07D309/08
Domestic Patent References:
WO2014028669A12014-02-20
WO2013045431A12013-04-04
WO2011115892A12011-09-22
WO2014095757A12014-06-26
Foreign References:
US6403607B12002-06-11
US20090042851A12009-02-12
US20070185136A12007-08-09
US20050037925A12005-02-17
US6392010B12002-05-21
Other References:
YANG, S. M. ET AL.: "Microwave assisted ring-opening of epoxides with N- biaryl sulfonamides in the synthesis of matrix metalloproteinase-9 inhibitors", TETRAHEDRON LETTERS, vol. 49, no. 5, 2008, pages 835 - 839, XP022413154
DATABASE CAS 6 April 2008 (2008-04-06), "Chemical name: Benzenesulfonamide, N-[4-[(2-fluorophenyl)methoxy]phenyl]-N-methyl- whole document", XP055399213, retrieved from STN Database accession no. 1012413-39-6
See also references of EP 3209641A4
Attorney, Agent or Firm:
DAVIS, Chad, E. et al. (Goodwin Procter LLP, Exchange PlaceBoston, MA, 02109, US)
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