BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS

Title:

BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS

Document Type and Number:

WIPO Patent Application WO/2012/174312

Kind Code:

A3

Abstract:

Provided are compounds of Formulas I, II, III, IV, V, and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV). Also provided are synthetic intermediates, methods for preparing the compounds of any of Formulas I, II, III, IV and V or a pharmaceutically acceptable salt or solvate thereof, and compositions thereof and for their therapeutic uses.

Inventors:

BOTYANSZKI JANOS (US)
DICKERSON SCOTT HOWARD (US)
LEIVERS MARTIN ROBERT (US)
LI XIAOFEI (CA)
MCFADYEN ROBERT BLOUNT (US)
REDMAN ANIKO MARIA (US)
SHOTWELL JOHN BRADFORD (US)
XUE JIANJUN (CN)

Application Number:

PCT/US2012/042558

Publication Date:

February 28, 2013

Filing Date:

June 15, 2012

Export Citation:

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Assignee:

GLAXOSMITHKLINE LLC (US)
BOTYANSZKI JANOS (US)
DICKERSON SCOTT HOWARD (US)
LEIVERS MARTIN ROBERT (US)
LI XIAOFEI (CA)
MCFADYEN ROBERT BLOUNT (US)
REDMAN ANIKO MARIA (US)
SHOTWELL JOHN BRADFORD (US)
XUE JIANJUN (CN)

International Classes:

C07D401/04

Domestic Patent References:

WO2010100144A1	2010-09-10
WO2010133318A1	2010-11-25

Foreign References:

US20090163489A1	2009-06-25
US7687638B2	2010-03-30
US20070093659A1	2007-04-26
US6166219A	2000-12-26

Attorney, Agent or Firm:

THOMAS, Robert (Steve) et al. (Global PatentsFive Moore Drive,PO Box 1339, Research Triangle Park North Carolina, US)

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