Title:
BENZIMIDAZOLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/021615
Kind Code:
A1
Abstract:
Compounds useful in the treatment of various PARP-related diseases, which are benzimidazole derivatives having heterocyclic groups at the 2-position and carbamoyl at the 4-position as represented by general formula (I) or (II) or salts thereof, wherein R?1¿ is H, lower alkyl, or the like; R?2¿ is H, lower alkyl, or the like; and A is an optionally substituted heterocyclic group or the like.
Inventors:
TAKAYAMA KAZUHISA (JP)
KOGA YUJI (JP)
MASUDA NAOYUKI (JP)
MIYAZAKI YOJI (JP)
KIMURA TAKENORI (JP)
NAGASHIMA SHINYA (JP)
OKAMOTO YOSHINORI (JP)
OKADA YOHEI (JP)
TAKEUCHI MAKOTO (JP)
KOGA YUJI (JP)
MASUDA NAOYUKI (JP)
MIYAZAKI YOJI (JP)
KIMURA TAKENORI (JP)
NAGASHIMA SHINYA (JP)
OKAMOTO YOSHINORI (JP)
OKADA YOHEI (JP)
TAKEUCHI MAKOTO (JP)
Application Number:
PCT/JP2000/006319
Publication Date:
March 29, 2001
Filing Date:
September 14, 2000
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
TAKAYAMA KAZUHISA (JP)
KOGA YUJI (JP)
MASUDA NAOYUKI (JP)
MIYAZAKI YOJI (JP)
KIMURA TAKENORI (JP)
NAGASHIMA SHINYA (JP)
OKAMOTO YOSHINORI (JP)
OKADA YOHEI (JP)
TAKEUCHI MAKOTO (JP)
TAKAYAMA KAZUHISA (JP)
KOGA YUJI (JP)
MASUDA NAOYUKI (JP)
MIYAZAKI YOJI (JP)
KIMURA TAKENORI (JP)
NAGASHIMA SHINYA (JP)
OKAMOTO YOSHINORI (JP)
OKADA YOHEI (JP)
TAKEUCHI MAKOTO (JP)
International Classes:
A61P29/00; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D417/04; C07D417/14; (IPC1-7): C07D401/04; A61K31/4184; A61K31/423; A61K31/427; A61K31/428; A61K31/4375; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/497; A61K31/498; A61K31/501; A61K31/502; A61K31/506; A61K31/517; A61P29/00; A61P43/00; C07D401/14; C07D403/04; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D417/04; C07D417/14; C07D451/00; C07D451/02; C07D451/14; C07D453/02; C07D487/04
Domestic Patent References:
| WO1997004771A1 | 1997-02-13 | |||
| WO2000032579A1 | 2000-06-08 |
Other References:
DENNY W.A. ET AL.: "Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of minimal DNA-intercalating agents which may not act via topoisomerase II", J. MED. CHEM., vol. 33, no. 2, 1990, pages 814 - 819, XP002934285
Attorney, Agent or Firm:
Nagai, Shozo (Ltd. Patent Dept. 17-1 Hasune 3-chome Itabashi-ku, Tokyo, JP)
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