Title:
BENZIMIDAZOLE SUBSTITUTION-BASED PHENYL N-BUTYRAMIDE COMPOUND AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/037127
Kind Code:
A1
Abstract:
The present disclosure relates to a benzimidazole substitution-based phenyl n-butyramide compound and a preparation method therefor. The method of the present disclosure avoids a nitration and polyphosphoric acid cyclization reaction, and avoids the production of a large amount of waste acid reaction liquid from the source. The synthesis method embodied in the present invention has the advantages of being simple and highly efficient, having mild conditions and producing less pollutants, and so on, and is suitable for development as a green and sustainable production process.
Inventors:
SHEN JINGSHAN (CN)
SUN CHANGLIANG (CN)
ZHU FUQIANG (CN)
ZHANG JUNCHI (CN)
LI RUI (CN)
SUN CHANGLIANG (CN)
ZHU FUQIANG (CN)
ZHANG JUNCHI (CN)
LI RUI (CN)
Application Number:
PCT/CN2020/111668
Publication Date:
March 04, 2021
Filing Date:
August 27, 2020
Export Citation:
Assignee:
TOPHARMAN SHANGHAI CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
TOPHARMAN TANCHENG CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
TOPHARMAN TANCHENG CO LTD (CN)
International Classes:
C07D235/18
Foreign References:
| CN107434786A | 2017-12-05 | |||
| CN102229570A | 2011-11-02 | |||
| CN101074213A | 2007-11-21 | |||
| CN101743228A | 2010-06-16 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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