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Title:
BENZODIAZEPINE DERIVATIVES AND USES THEREOF IN MEDICAL FIELD
Document Type and Number:
WIPO Patent Application WO2007015280
Kind Code:
A8
Abstract:
The invention concerns benzodiazepine derivatives of formula (I) wherein Y it is SO2 or NR, wherein R is H or C1-C6 alkyl; X is H, C1-C12 alkyl, -CO, -SO, -SO2, or - CO-R2, SO-R2, SO2- R2, wherein R2 is selected from H, C1-C12 alkyl, (C3-C8 cycloalkyl) C0-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with 0 to 3 substituents selected from halogen, -CN, -NH2, -OH, -NO2, COOR3, wherein R3 is selected from H, C1-C12 alkyl, (C3-C8 cycloalkyl) C0-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, or C2-C6 alkoxy carbonyl; phenyl, benzyl, naphtyl, biphenyl, or heterocycle, n is 0-6; R4 is selected from H, OH, COOH, CN, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkoxycarbonyl, -CO, -SO, - SO2, or -CO-R5, SO-R5, SO2-R2, -OCO-R5, OSO-R5, OSO2-R5, COOR5, SOOR5, SO2OR5, NHR5, NHCOR5, NHSO2R5, SR5, SCOR5, wherein R5 is selected from H, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, or C2-C6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with O to 3 substituents selected from halogen, -CN, -NH2, -OH, -NO2, COOR5', wherein R5 is selected from H, C1-C12 alkyl, (C3-C8 cycloalkyl) C0-C6 alkyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, or C2-C6 alkoxy carbonyl; R6 and R7 independently of each other are selected from the group consisting of H, OH, halogen, CN, NH2, NO2, COOR3, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, and C2-C6 alkoxy carbonyl; R3 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or physiologically acceptable salts and uses thereof in medical field, particularly as anti-tumoral agents.

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Inventors:
SILVESTRI ROMANO (IT)
MARFE GABRIELLA (IT)
ABRUZZESE ELISABETTA (IT)
CATALANO GIANFRANCO (IT)
DI STEFANO CARLA (IT)
NOVELLINO ETTORE (IT)
SINIBALDI SALIMEI PAOLA (IT)
DE MARTINO MARIA GABRIELLA (IT)
LA REGINA GIUSEPPE (IT)
LAVECCHIA ANTONIO (IT)
Application Number:
PCT/IT2006/000401
Publication Date:
April 10, 2008
Filing Date:
May 26, 2006
Export Citation:
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Assignee:
UNIV ROMA (IT)
SILVESTRI ROMANO (IT)
MARFE GABRIELLA (IT)
ABRUZZESE ELISABETTA (IT)
CATALANO GIANFRANCO (IT)
DI STEFANO CARLA (IT)
NOVELLINO ETTORE (IT)
SINIBALDI SALIMEI PAOLA (IT)
DE MARTINO MARIA GABRIELLA (IT)
LA REGINA GIUSEPPE (IT)
LAVECCHIA ANTONIO (IT)
International Classes:
C07D513/04; A61K31/55; A61P35/02; C07D487/04
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