Title:
BENZOFUROXAN OXIDE HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/112768
Kind Code:
A1
Abstract:
The present invention relates to a benzofuroxan oxide histone deacetylase inhibitor, and a preparation method therefor and uses thereof. The compound has a structure represented by a formula I or I', a tautomer II represented by the formula I, and a tautomer II' represented by the formula I'. The present invention further relates to a pharmaceutical composition comprising a compound with a structure represented by the formula I, I', II or II'. The compound of the present invention is used for preparing a drug for preventing or treating mammalian diseases associated with the abnormal expression of the histone deacetylase activity.
Inventors:
ZHANG YINGJIE (CN)
XU WENFANG (CN)
DUAN WENWEN (CN)
XU WENFANG (CN)
DUAN WENWEN (CN)
Application Number:
PCT/CN2015/097619
Publication Date:
July 21, 2016
Filing Date:
December 16, 2015
Export Citation:
Assignee:
UNIV SHANDONG (CN)
International Classes:
C07D271/12; A61K31/4245; A61P3/10; A61P25/00; A61P25/28; A61P29/00; A61P31/12; A61P33/06; A61P35/00; A61P35/02
Foreign References:
| CN104592145A | 2015-05-06 | |||
| CN1301258A | 2001-06-27 |
Other References:
DUAN, WENWEN ET AL.: "Synthesis and Biological Evaluation of Novel Histone Deacetylases Inhibitors with Nitric Oxide Releasing Activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 15, 1 August 2015 (2015-08-01), pages 4481 - 4488
EL-ABADELAH, M.M. ET AL.: "Chiroptical Properties of Some N-5(6)Benzofuroxanoyl-L-a-Amino Acids and Esters (1", J. HETEROCYCLIC CHEM., vol. 17, no. 2, 31 March 1980 (1980-03-31), pages 213 - 217
EL-ABADELAH, M.M.: "Chiroptical Properties of Some N-5(6)Benzofuroxanoyl-L-a-Amino Acids and Esters (1", J. HETEROCYCLIC CHEM., vol. 17, no. 2, 31 March 1980 (1980-03-31), pages 213 - 217
GHOSH, P.B. ET AL.: "Potential Antileukemic and Immunosuppressive Drugs. Preparation and in Vitro Pharmacological Activity of Some Benzo-2,1,3-oxadiazoles (Benzofurazans) and Their N-Oxides (Benzofuroxans", JOURNAL OF MEDICINAL CHEMISTRY, vol. 11, no. 2, 31 December 1968 (1968-12-31), pages 305 - 311
EL-ABADELAH, M.M. ET AL.: "Chiroptical Properties of Some N-5(6)Benzofuroxanoyl-L-a-Amino Acids and Esters (1", J. HETEROCYCLIC CHEM., vol. 17, no. 2, 31 March 1980 (1980-03-31), pages 213 - 217
EL-ABADELAH, M.M.: "Chiroptical Properties of Some N-5(6)Benzofuroxanoyl-L-a-Amino Acids and Esters (1", J. HETEROCYCLIC CHEM., vol. 17, no. 2, 31 March 1980 (1980-03-31), pages 213 - 217
GHOSH, P.B. ET AL.: "Potential Antileukemic and Immunosuppressive Drugs. Preparation and in Vitro Pharmacological Activity of Some Benzo-2,1,3-oxadiazoles (Benzofurazans) and Their N-Oxides (Benzofuroxans", JOURNAL OF MEDICINAL CHEMISTRY, vol. 11, no. 2, 31 December 1968 (1968-12-31), pages 305 - 311
Attorney, Agent or Firm:
JINAN JINDI INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
济南金迪知识产权代理有限公司 (CN)
济南金迪知识产权代理有限公司 (CN)
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