Title:
BENZONAPHTHACENEGLYCOSIDE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/028229
Kind Code:
A1
Abstract:
A dicarboxylic acid compound obtained by oxidative decomposition of the second sugar residue of the sugar chain of a pradimicin group antibiotic, namely, an antibiotic composed of a benzonaphthacenequinone skeleton, D-amino acid side chain and sugar chain; and a use thereof utilizing its microbe-specific binding capability. This dicarboxylic acid compound exhibits a water solubility significantly enhanced over that of the raw antibiotic while retaining the microbe-specific binding capability.
More Like This:
| JPS60132998 | ANTHRACYCLINE DERIVATIVE |
| JP2005504006 | Prodrug binding by acylation with synnamete |
Inventors:
OKI TOSHIKAZU (JP)
IGARASHI YASUHIRO (JP)
FURUMAI TAMOTSU (JP)
IGARASHI YASUHIRO (JP)
FURUMAI TAMOTSU (JP)
Application Number:
PCT/JP2005/016673
Publication Date:
March 16, 2006
Filing Date:
September 05, 2005
Export Citation:
Assignee:
OKI TOSHIKAZU (JP)
IGARASHI YASUHIRO (JP)
FURUMAI TAMOTSU (JP)
IGARASHI YASUHIRO (JP)
FURUMAI TAMOTSU (JP)
International Classes:
C07H15/252
Foreign References:
| JP2000001497A | 2000-01-07 |
Other References:
TOSHIKAZU OKI: "Lectin-yo Motsu Teibunshi Busshitsu Pradimicin. (Sugar-Recognizing Antibiotics, pradimicins)", PROTEIN NUCLEIC ACID AND ENZYME, vol. 39, no. 6, May 1994 (1994-05-01), pages 973 - 978, XP002998282
KARLOWSKY J.A. ET AL: "In Vitro Antifungal Activity of BMS-181184 against Systemic Isolates of Candida,Cryptococcus, and Blastomyces Species", DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, vol. 28, no. 4, 1997, pages 179 - 182, XP002998283
KARLOWSKY J.A. ET AL: "In Vitro Antifungal Activity of BMS-181184 against Systemic Isolates of Candida,Cryptococcus, and Blastomyces Species", DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, vol. 28, no. 4, 1997, pages 179 - 182, XP002998283
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
Download PDF: