Title:
BENZOPIPERIDINE OR HETEROARYLPIPERIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/223715
Kind Code:
A1
Abstract:
The present invention relates to a benzopiperidine or heteroarylpiperidine derivative, a preparation method therefor, and a medical application thereof. In particular, the present invention relates to a benzopiperidine derivative or a heteroarylpiperidine derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and use thereof as an estrogen receptor modulator in the prevention and/or treatment of estrogen receptor mediated or dependent diseases or conditions, the diseases particularly and preferably being breast cancers. The definition of each substituent in general formula (I) is the same as that in the description.
Inventors:
YANG FANGLONG (CN)
LI XIAODONG (CN)
WANG WEIMIN (CN)
CHEN GANG (CN)
HE FENG (CN)
TAO WEIKANG (CN)
LI XIAODONG (CN)
WANG WEIMIN (CN)
CHEN GANG (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2019/087944
Publication Date:
November 28, 2019
Filing Date:
May 22, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/04; A61K31/4725; A61P35/00
Domestic Patent References:
| WO2017107754A1 | 2017-06-29 | |||
| WO2015092634A1 | 2015-06-25 | |||
| WO2010138659A1 | 2010-12-02 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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