Title:
BENZOTHIAZINONE DERIVATIVE SUBSTITUTED WITH TRIFLUOROMETHYL AT 6-POSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/204902
Kind Code:
A1
Abstract:
A benzothiazinone derivative substituted with trifluoromethyl at 6-position, and a preparation method therefor and the use thereof. A series of compounds are obtained by means of changing the benzene ring of the benzothiazinone backbone, especially by means of changing a substituent thereof. Compared with other benzothiazinone derivatives, the benzothiazinone derivative substituted with trifluoromethyl at 6-position is more stable with regard to hepatic microsomal enzymes, and has longer metabolic half-life T1/2 and better water solubility.
Inventors:
QIAO CHUNHUA (CN)
FAN DONGGUANG (CN)
FAN DONGGUANG (CN)
Application Number:
PCT/CN2021/083695
Publication Date:
October 06, 2022
Filing Date:
March 29, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07D279/08; A61K31/5415; A61P31/06; C07D417/12
Foreign References:
| CN113121521A | 2021-07-16 | |||
| CN112409293A | 2021-02-26 | |||
| CN101809009A | 2010-08-18 | |||
| DE102014012546A1 | 2016-03-31 | |||
| US20150353571A1 | 2015-12-10 | |||
| CN111269197A | 2020-06-12 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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