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Title:
BENZOTHIAZOLE COMPOUND AND MEDICINE CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2016/010092
Kind Code:
A1
Abstract:
Provided are: a compound that is useful as an amyloid oxidation catalyst which can be applied inside a living body and can be applied not only to Aβ peptides but also to other amyloids; and an amyloid-related preventive or therapeutic drug using said compound. A benzothiazole compound which is represented by general formula (1) (in the formula, X represents a halogen atom; R1 represents a hydrocarbon group which may have a substituent; R2 represents a hydrogen atom or a hydrocarbon group which may have a substituent; R3 and R4 are the same or different and represent a hydrogen atom, an alkoxy group, a halogen atom, an amino group, a nitro group, a cyano group, or a hydrocarbon group which may have a substituent; R2 and R4 together may form an alkylene group, and R5 represents an anion).

Inventors:
KANAI MOTOMU (JP)
SOMA YOHEI (JP)
TANIGUCHI ATSUHIKO (JP)
SHIMIZU YUSUKE (JP)
Application Number:
PCT/JP2015/070317
Publication Date:
January 21, 2016
Filing Date:
July 15, 2015
Export Citation:
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Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
International Classes:
C07D417/04; A61K31/4725; A61K31/4745; A61K38/00; A61P3/00; A61P25/14; A61P25/16; A61P25/28; C07D455/04; C07K7/06; C07K14/47
Foreign References:
JP2010085465A2010-04-15
JP2002202598A2002-07-19
JP2010528015A2010-08-19
JP2009516684A2009-04-23
JP2005514330A2005-05-19
Other References:
SRIVASTAVA,A. ET AL.: "Identifying the Bond Responsible for the Fluorescence Modulation in an Amyloid Fibril Sensor", CHEMISTRY - A EUROPEAN JOURNAL, vol. 16, no. 30, 2010, pages 9257 - 9263, XP055309102
GARMAISE,D.L. ET AL.: "Anthelmintic quaternary salts. III. Benzothiazolium salts", JOURNAL OF MEDICINAL CHEMISTRY, vol. 12, no. 1, 1969, pages 30 - 36, XP055199292, DOI: doi:10.1021/jm00301a008
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
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