Title:
BENZOTHIAZOLE MEROTERPENOID COMPOUND AND DERIVATIVE THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/057223
Kind Code:
A1
Abstract:
A benzothiazole meroterpenoid compound derived from deep sea fungi and a derivative thereof, and a preparation method therefor and the use thereof in the preparation of an anti-tumor drug. The benzothiazole meroterpenoid compound is a compound as represented by formulas I to III or a salt thereof. The compound is isolated from a fermentation product of deep-sea-derived Penicillium allii-sativi and inhibits the transcriptional activity of an anti-tumor target RXRalpha by means of binding thereto so as to achieve a remarkable anti-tumor effect. The compound can be used for preparing, researching and developing anti-cancer drugs, and has good application prospects.
Inventors:
YANG XIAN WEN (CN)
XIE CHUN LAN (CN)
YAN QING XIANG (CN)
ZOU ZHEN BIAO (CN)
HE ZHI HUI (CN)
XIE CHUN LAN (CN)
YAN QING XIANG (CN)
ZOU ZHEN BIAO (CN)
HE ZHI HUI (CN)
Application Number:
PCT/CN2021/081434
Publication Date:
March 24, 2022
Filing Date:
March 18, 2021
Export Citation:
Assignee:
THIRD INSTITUTE OF OCEANOGRAPHY MINI OF NATURAL RESOURCES (CN)
International Classes:
C07D277/68; A61K31/426; A61P35/00; C07D277/62; C12P17/14; C12R1/80
Domestic Patent References:
| WO2009157527A1 | 2009-12-30 | |||
| WO2015171474A1 | 2015-11-12 |
Foreign References:
| CN112047901A | 2020-12-08 | |||
| CN109942658A | 2019-06-28 | |||
| CN107021937A | 2017-08-08 |
Attorney, Agent or Firm:
GUANGZHOU HEBEN INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNER) (CN)
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