Title:
BENZOTHIAZOLYL BIARYL COMPOUND, AND PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2021/218110
Kind Code:
A1
Abstract:
A benzothiazolyl biaryl compound represented by general formula I, or a pharmaceutically acceptable salt thereof, or an enantiomer, a diastereoisomer, a tautomer, a torsional isomer, a solvate, a polymorph, or a prodrug thereof, a preparation method therefor, and a use thereof as a KRASG12C inhibitor.
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Inventors:
WAN HUIXIN (CN)
ZHA CHUANTAO (CN)
MA JINGUI (CN)
SHEN JINGKANG (CN)
ZHA CHUANTAO (CN)
MA JINGUI (CN)
SHEN JINGKANG (CN)
Application Number:
PCT/CN2020/127861
Publication Date:
November 04, 2021
Filing Date:
November 10, 2020
Export Citation:
Assignee:
SHANGHAI RINGENE BIOPHARMA CO LTD (CN)
SHANGHAI RINGENE THERAPEUTICS CO LTD (CN)
SHANGHAI RINGENE THERAPEUTICS CO LTD (CN)
International Classes:
C07D417/14; A61K31/517; A61P35/00; C07D215/02; C07D215/12; C07D239/72; C07D277/62
Domestic Patent References:
| WO2020081282A1 | 2020-04-23 | |||
| WO2020146613A1 | 2020-07-16 | |||
| WO2019110751A1 | 2019-06-13 | |||
| WO2019014402A1 | 2019-01-17 | |||
| WO2013067597A1 | 2013-05-16 | |||
| WO2020081282A1 | 2020-04-23 |
Foreign References:
| CN106488910A | 2017-03-08 | |||
| TW201938561A | 2019-10-01 | |||
| CN110869358A | 2020-03-06 | |||
| CN110036010A | 2019-07-19 | |||
| CN202010358615A | 2020-04-29 |
Other References:
AMERICAN SOCIETY OF CLINICAL ONCOLOGY, June 2019 (2019-06-01)
GREENWALD, R. B. ET AL., J. MED. CHEM., vol. 43, 2000, pages 475
"Methods and Protocols, Methods in Molecular Biology", vol. 243, 2004, article "Chiral Separations"
A.M. STALCUPCHIRAL SEPARATIONS: "Rev. Anal. Chem.", vol. 3, 2010, pages: 341 - 63
"VOGEL'S ENCYCLOPEDIA OF PRACTICAL ORGANIC CHEMISTRY", 1991, LONGMAN SCIENTIFIC AND TECHNICAL LTD., pages: 809 - 816
HELLER, ACC. CHEM. RES., vol. 23, 1990, pages 128
SAULNIER, M. G. ET AL., BIOORG. MED. CHEM. LETT., vol. 4, 1994, pages 1985 - 1990
GREENE, T. WP. G. M. WUTS: "Goodman and Gilman, The Pharmacological Basis of Therapeutics", 1999, MACK PUBLISHING CO.
GREENWALD, R. B. ET AL., J. MED. CHEM., vol. 43, 2000, pages 475
"Methods and Protocols, Methods in Molecular Biology", vol. 243, 2004, article "Chiral Separations"
A.M. STALCUPCHIRAL SEPARATIONS: "Rev. Anal. Chem.", vol. 3, 2010, pages: 341 - 63
"VOGEL'S ENCYCLOPEDIA OF PRACTICAL ORGANIC CHEMISTRY", 1991, LONGMAN SCIENTIFIC AND TECHNICAL LTD., pages: 809 - 816
HELLER, ACC. CHEM. RES., vol. 23, 1990, pages 128
SAULNIER, M. G. ET AL., BIOORG. MED. CHEM. LETT., vol. 4, 1994, pages 1985 - 1990
GREENE, T. WP. G. M. WUTS: "Goodman and Gilman, The Pharmacological Basis of Therapeutics", 1999, MACK PUBLISHING CO.
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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