BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES

Title:

BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES

Document Type and Number:

WIPO Patent Application WO2006115835

Kind Code:

A3

Abstract:

The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

Inventors:

HUBBS JED LEE (US)
KATTAR SAM (US)
METHOT JOEY (US)
MILLER THOMAS (US)
SILIPHAIVANH PHIENG (US)
STANTON MATTHEW (US)
WILSON KEVIN (US)
WITTER DAVID J (US)

Application Number:

PCT/US2006/014093

Publication Date:

December 14, 2006

Filing Date:

April 14, 2006

Export Citation:

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Assignee:

MERCK & CO INC (US)
ATON PHARMA INC (US)
HUBBS JED LEE (US)
KATTAR SAM (US)
METHOT JOEY (US)
MILLER THOMAS (US)
SILIPHAIVANH PHIENG (US)
STANTON MATTHEW (US)
WILSON KEVIN (US)
WITTER DAVID J (US)

International Classes:

A61K31/38; C07D333/56; A61K31/41; C07D271/10

Foreign References:

US7105564B1	2006-09-12
US7019026B1	2006-03-28
US6730670B2	2004-05-04

Other References: