Title:
BENZOXAZINONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2009/044788
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases. [MEANS FOR SOLVING PROBLEMS] The compound, which is for use as an active ingredient, is represented by the formula (I): [wherein R1 represents optionally halogenated C1-6 alkyl, etc.; R2 represents, e.g., a group represented by the formula (II-1) or (II-4) (wherein W represents C1-6 alkylene, etc. and R represents C1-6 alkyl, etc.); R3 represents hydrogen, C1-6 alkyl, etc.; X represents -O-, -NH-, etc.; and Y1, Y2, Y3, and Y4 each independently represents -CH-, -N-, etc.].
Inventors:
ISHIKAWA SHIHO (JP)
MIZUTANI TAKASHI (JP)
NAGASE TSUYOSHI (JP)
SATO NAGAAKI (JP)
TAKAHASHI HIDEKAZU (JP)
MIZUTANI TAKASHI (JP)
NAGASE TSUYOSHI (JP)
SATO NAGAAKI (JP)
TAKAHASHI HIDEKAZU (JP)
Application Number:
PCT/JP2008/067883
Publication Date:
April 09, 2009
Filing Date:
October 02, 2008
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
ISHIKAWA SHIHO (JP)
MIZUTANI TAKASHI (JP)
NAGASE TSUYOSHI (JP)
SATO NAGAAKI (JP)
TAKAHASHI HIDEKAZU (JP)
ISHIKAWA SHIHO (JP)
MIZUTANI TAKASHI (JP)
NAGASE TSUYOSHI (JP)
SATO NAGAAKI (JP)
TAKAHASHI HIDEKAZU (JP)
International Classes:
C07D239/80; A61K31/517; A61K31/536; A61P1/00; A61P1/04; A61P1/10; A61P1/16; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/00; A61P5/24; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P15/08; A61P15/10; A61P17/02; A61P19/02; A61P19/06; A61P25/00; A61P25/02; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P33/00; A61P35/00; A61P37/08; A61P43/00; C07D265/18; C07D403/04; C07D413/04; C07D413/12; C07D413/14; C07D417/12; C07D498/04
Domestic Patent References:
| WO2006098969A2 | 2006-09-21 | |||
| WO1995012583A1 | 1995-05-11 | |||
| WO1995020389A1 | 1995-08-03 | |||
| WO1993004047A1 | 1993-03-04 | |||
| WO2000066571A1 | 2000-11-09 | |||
| WO2004013347A2 | 2004-02-12 |
Foreign References:
| EP0569083A1 | 1993-11-10 | |||
| EP0582455A1 | 1994-02-09 | |||
| EP0530994A1 | 1993-03-10 | |||
| JP2002543193A | 2002-12-17 |
Other References:
MATSUZAKA,T. ET AL.: "Crucial role of a long- chain fatty acid elongase, Elovl6, in obesity- induced insulin resistance", NATURE MEDICINE, vol. 13, no. 10, 1 October 2007 (2007-10-01), pages 1193 - 202, XP008132558
MOON,Y. ET AL.: "Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 48, 2001, pages 45358 - 45366, XP002963525
J. BIOL. CHEM., vol. 276, no. 48, 2001, pages 45358 - 45366
"The Merck Manual of Medical Information", 2003, MERCK & CO.
J. ORG. CHEM., vol. 63, 1998, pages 8536
NOBUO IZUMIYA ET AL.: "Pepuchido Gosei no Kiso to Jikken", 1983, MARUZEN CO., LTD.
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS
MOON, J. BIOL. CHEM., vol. 276, 2001, pages 45358 - 45366
TETRAHEDRON LETT., vol. 44, 2003, pages 7147
See also references of EP 2210880A4
MOON,Y. ET AL.: "Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 48, 2001, pages 45358 - 45366, XP002963525
J. BIOL. CHEM., vol. 276, no. 48, 2001, pages 45358 - 45366
"The Merck Manual of Medical Information", 2003, MERCK & CO.
J. ORG. CHEM., vol. 63, 1998, pages 8536
NOBUO IZUMIYA ET AL.: "Pepuchido Gosei no Kiso to Jikken", 1983, MARUZEN CO., LTD.
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS
MOON, J. BIOL. CHEM., vol. 276, 2001, pages 45358 - 45366
TETRAHEDRON LETT., vol. 44, 2003, pages 7147
See also references of EP 2210880A4
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (1-13-12 Kudankit, Chiyoda-ku Tokyo 67, JP)
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