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Title:
BENZOXAZINONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2009/044788
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases. [MEANS FOR SOLVING PROBLEMS] The compound, which is for use as an active ingredient, is represented by the formula (I): [wherein R1 represents optionally halogenated C1-6 alkyl, etc.; R2 represents, e.g., a group represented by the formula (II-1) or (II-4) (wherein W represents C1-6 alkylene, etc. and R represents C1-6 alkyl, etc.); R3 represents hydrogen, C1-6 alkyl, etc.; X represents -O-, -NH-, etc.; and Y1, Y2, Y3, and Y4 each independently represents -CH-, -N-, etc.].

Inventors:
ISHIKAWA, Shiho (LTD. Tsukuba Research Institute 3, Okub, Tsukuba-shi Ibaraki 11, 3002611, JP)
石川 史歩 (〒11 茨城県つくば市大久保3番地 萬有製薬株式会社つくば研究所内 Ibaraki, 3002611, JP)
MIZUTANI, Takashi (LTD. Tsukuba Research Institute 3, Okub, Tsukuba-shi Ibaraki 11, 3002611, JP)
水谷 尊志 (〒11 茨城県つくば市大久保3番地 萬有製薬株式会社つくば研究所内 Ibaraki, 3002611, JP)
NAGASE, Tsuyoshi (LTD. Tsukuba Research Institute 3, Okub, Tsukuba-shi Ibaraki 11, 3002611, JP)
Application Number:
JP2008/067883
Publication Date:
April 09, 2009
Filing Date:
October 02, 2008
Export Citation:
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Assignee:
BANYU PHARMACEUTICAL CO., LTD. (Kitanomaru Square, 1-13-12 Kudankit, Chiyoda-kuTokyo 67, 1028667, JP)
萬有製薬株式会社 (〒67 東京都千代田区九段北一丁目13番12号 北の丸スクエア Tokyo, 1028667, JP)
ISHIKAWA, Shiho (LTD. Tsukuba Research Institute 3, Okub, Tsukuba-shi Ibaraki 11, 3002611, JP)
石川 史歩 (〒11 茨城県つくば市大久保3番地 萬有製薬株式会社つくば研究所内 Ibaraki, 3002611, JP)
MIZUTANI, Takashi (LTD. Tsukuba Research Institute 3, Okub, Tsukuba-shi Ibaraki 11, 3002611, JP)
水谷 尊志 (〒11 茨城県つくば市大久保3番地 萬有製薬株式会社つくば研究所内 Ibaraki, 3002611, JP)
International Classes:
C07D239/80; A61K31/517; A61K31/536; A61P1/00; A61P1/04; A61P1/10; A61P1/16; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/00; A61P5/24; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P15/08; A61P15/10; A61P17/02; A61P19/02; A61P19/06; A61P25/00; A61P25/02; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P33/00; A61P35/00; A61P37/08; A61P43/00; C07D265/18; C07D403/04; C07D413/04; C07D413/12; C07D413/14; C07D417/12; C07D498/04
Domestic Patent References:
WO2006098969A2
WO1995012583A1
WO1995020389A1
WO1993004047A1
WO2000066571A1
WO2004013347A2
Foreign References:
EP0569083A1
EP0582455A1
EP0530994A1
JP2002543193A
Other References:
MATSUZAKA,T. ET AL.: "Crucial role of a long- chain fatty acid elongase, Elovl6, in obesity- induced insulin resistance", NATURE MEDICINE, vol. 13, no. 10, 1 October 2007 (2007-10-01), pages 1193 - 202, XP008132558
MOON,Y. ET AL.: "Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 48, 2001, pages 45358 - 45366, XP002963525
See also references of EP 2210880A4
J. BIOL. CHEM., vol. 276, no. 48, 2001, pages 45358 - 45366
"The Merck Manual of Medical Information", 2003, MERCK & CO.
J. ORG. CHEM., vol. 63, 1998, pages 8536
NOBUO IZUMIYA ET AL.: "Pepuchido Gosei no Kiso to Jikken", 1983, MARUZEN CO., LTD.
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS
MOON, J. BIOL. CHEM., vol. 276, 2001, pages 45358 - 45366
TETRAHEDRON LETT., vol. 44, 2003, pages 7147
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (Kitanomaru Square, 1-13-12 Kudankit, Chiyoda-ku Tokyo 67, 1028667, JP)
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