BENZOYLETHYLENE DERIVATIVE

WIPO Patent Application WO/1996/003364

A1

A benzoylethylene derivative represented by general formula (I) and a salt thereof wherein R1 to R5 represent each hydrogen, -OR9 (R9 being hydrogen, C1-C5 alkyl, etc.), etc.; R6 represents hydrogen, C1-C5 alkyl, etc.; R7 represents hydrogen, cyano, C1-C5 alkyl, -SOqR15 (q being 0, 1 or 2, and R15 being thienyl, phenyl, etc.), etc.; and R8 represents cyano, -CR22R23X (R22 and R23 being each hydrogen, C1-C5 alkyl, etc., and X being -NR24R25 (wherein R24 and R25 represent each C1-C5 alkyl, or R24 and R25 are combined together to represent alkylene, etc.)), etc. The derivative has potent activities of tyrosine kinase inhibition and cancer cell growth inhibition and is useful as a carcinostatic agent.

JPS57149249	1,8-DIHYDROXY-9-ANTHRONE DERIVATIVE AND MEDICINAL, VETERINARY AND COSMETIC COMPOSITION CONTAINING SAME
JP4905426	Methods for producing glutamic acid compounds and their production intermediates, and new intermediates for that purpose.
WO/1997/043239	INHIBITION OF MATRIX METALLOPROTEASES BY SUBSTITUTED BIARYL OXOBUTYRIC ACIDS

KITANO YASUNORI (JP)
INOKAWA HARUKI (JP)
TAKAYANAGI HISAO (JP)
YANO TAMAKI (JP)
UMEKI HIROE (JP)
HARA HIROTO (JP)

PCT/JP1995/001475

February 08, 1996

July 25, 1995

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MITSUBISHI CHEM CORP (JP)
KITANO YASUNORI (JP)
INOKAWA HARUKI (JP)
TAKAYANAGI HISAO (JP)
YANO TAMAKI (JP)
UMEKI HIROE (JP)
HARA HIROTO (JP)

C07C59/90; C07C69/738; C07C225/16; C07C225/20; C07C229/44; C07C235/78; C07C255/40; C07C255/41; C07C255/42; C07C255/43; C07C255/56; C07C317/28; C07C323/29; C07C323/62; C07D295/084; C07D295/104; C07D295/125; C07D295/135; C07D295/145; C07D333/34; (IPC1-7): C07C49/794; C07C49/835; C07C49/84; C07C69/738; C07C205/45; C07C225/16; C07C225/22; C07C235/78; C07C255/40; C07C255/42; C07C255/56; C07C255/58; C07C317/24; C07C317/28; C07C317/32; C07C323/22; C07C323/27; C07C323/32; C07C323/35; C07C323/39; A61K31/135; A61K31/165; A61K31/215; A61K31/275; A61K31/36; A61K31/38; A61K31/445; A61K31/535; C07D211/14; C07D295/104; C07D317/58; C07D333/34

JPS63130564A	1988-06-02
CS201121B1	1980-10-31

See also references of EP 0721930A4

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