Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
BENZYL DERIVATIVE COMPOUND CONTAINING ACTIVATED VINYL GROUP CAPABLE OF BEING USED FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS THROUGH NITRIC OXIDE GENERATION INHIBITION AND NRF2 ACTIVATION, AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/165140
Kind Code:
A1
Abstract:
The present invention relates to: a benzyl derivative containing an activated vinyl group; a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound as an active ingredient. The benzyl derivative is effective as an agent for preventing and treating neurological disorders caused by nerve cell dysfunction and death, particularly, Parkinson's disease, Alzheimer-type dementia, Huntington's disease, Lou Gehrig's disease, epilepsy, depression, insomnia, anxiety and neurodegenerative diseases through the application of nitric oxide generation inhibition and NF-E2-related factor-2 (Nrf2) activation.

Inventors:
KIM, Dong Jin (104-306 Taeneung Hyundai Hometown Sweet Apt, Gongneung 2-dong,Nowon-gu, Seoul 139-242, 139-242, KR)
PARK, Ki Duk (A-103, KIST Gwahakja Apt. 39-1, Hawolgok-dong,,Seongbjk-gu, Seoul 136-791, 136-791, KR)
PARK, Woong Seo (3 Kunyoung 3-cha Apt, Junggye 1-dong,Nowon-gu, Seoul 139-221, 139-221, KR)
KIM, Young Soo (108-302, Hyundai Fillgreen Apt. Mabuk-dong,,Giheung-gu, Yongin-si, Gyeonggi-do 446-561, 446-561, KR)
KIM, Jinwoo (206 Jeongsun Building, 1148-10 Jegi 1-dong,,Dongdaemun-gu, Seoul 130-060, 130-060, KR)
WOO, Seo Yeon (2 Sujeong Hanyang Apt, Seonbu 3-dong,Danwon-gu, Ansan-si, Gyeonggi-do 425-143, 425-143, KR)
HWANG, Onyou (9-1303, Gyeongnam Apt. Gaepo-dong,,Gangnam-gu, Seoul 135-240, 135-240, KR)
KIM, Yun Kyung (San19, Won-dong,Wonju-si, Gangwon-do 220-060, 220-060, KR)
BYEON, Seongrim (1 Hyundai 1-cha Apt, Wadong-ri Gyoha-eup,,Paju-si, Gyeonggi-do 413-833, 413-833, KR)
KANG, Yong Koo (301-406, Kunyoung 3-cha Apt. Junggye-dong,,Nowon-gu, Seoul 139-220, 139-220, KR)
Application Number:
KR2013/003676
Publication Date:
November 07, 2013
Filing Date:
April 29, 2013
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 136-791, 136-791, KR)
International Classes:
C07C317/28; A61K31/135; A61P25/00
Foreign References:
KR20030036993A
US20020022666A1
KR101043825B1
Other References:
XUE, Q. ET AL.: 'METAL-FREE, ONE-POT HIGHLY SELECTIVE SYNTHESIS OF (E)- VINYL SULFONES AND SULFOXIDES VIA ADDITION-OXIDATION OF THIOLS WITH ALKYNES' TETRAHEDRON LETTERS vol. 53, no. 14, 08 February 2012, pages 1851 - 1854
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (Hanmaum Bldg. 4F, 225 Baumoe-ro,Seocho-gu, Seoul 137-130, 137-130, KR)
Download PDF: