Title:
BENZYLAMINE DERIVATIVES, METHOD FOR OPTICAL RESOLUTION OF BENZYLAMINE DERIVATIVES, PROCESS FOR PRODUCTION OF BENZYLAMINE DERIVATIVES, PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE BENZYLAMINE DERIVATIVES, AND PROCESS FOR PRODUCTION OF (1R, 2S)-2-AMINO-1-(4-HYDROXYPHENYL)PROPAN-1-OL
Document Type and Number:
WIPO Patent Application WO/2007/000918
Kind Code:
A1
Abstract:
Benzylamine derivatives having structures represented by the general formula (1):
(1) a method for the optical resolution of benzylamine derivatives which comprises
using optically active mandelic acid as the reagent for optical resolution; and
a process for the production of optically active benzylamine derivatives which
comprises the optical resolution step of precipitating an optically active (S)-benzylamine
derivative represented by the general formula (3) as a salt thereof with (S)-mandelic
acid in a solution containing the corresponding benzylamine derivative of the
general formula (1) and (S)-mandelic acid: (3) wherein Ar is aryl of 6 to 15 carbon
atoms which may be substituted; and *1 represents an asymmetric carbon atom.
Inventors:
SUGIYAMA TERUAKI (JP)
FUJISHIMA AKINORI (JP)
UMETANI ATSUSHI (JP)
MATSUNAGA NOBUTAKA (JP)
OMORI YOSHIYUKI (JP)
SEKO NORIHIKO (JP)
FUJISHIMA AKINORI (JP)
UMETANI ATSUSHI (JP)
MATSUNAGA NOBUTAKA (JP)
OMORI YOSHIYUKI (JP)
SEKO NORIHIKO (JP)
Application Number:
PCT/JP2006/312367
Publication Date:
January 04, 2007
Filing Date:
June 20, 2006
Export Citation:
Assignee:
ALPS PHARMACEUTICAL IND CO LTD (JP)
SUGIYAMA TERUAKI (JP)
FUJISHIMA AKINORI (JP)
UMETANI ATSUSHI (JP)
MATSUNAGA NOBUTAKA (JP)
OMORI YOSHIYUKI (JP)
SEKO NORIHIKO (JP)
SUGIYAMA TERUAKI (JP)
FUJISHIMA AKINORI (JP)
UMETANI ATSUSHI (JP)
MATSUNAGA NOBUTAKA (JP)
OMORI YOSHIYUKI (JP)
SEKO NORIHIKO (JP)
International Classes:
C07C225/16; C07C213/00; C07C215/60; C07C221/00; C07B55/00; C07B57/00
Domestic Patent References:
| WO2003104186A1 | 2003-12-18 | |||
| WO1994001392A1 | 1994-01-20 |
Foreign References:
| JP2002535298A | 2002-10-22 | |||
| JP2003507357A | 2003-02-25 | |||
| JPH08208572A | 1996-08-13 |
Other References:
TAKEDA H. ET AL.: "EFFICIENT ASYMMETRIC HYDROGENATION OF alpha-AMINOACETOPHENONE DERIVATIVES LEADING TO PRACTICAL SYNTHESIS OF (S)-(-)-LEVAMISOLE", TETRAHEDRON LETTERS, vol. 30, no. 3, 1989, pages 363 - 366, XP003002751
NADKARNI D. ET AL.: "Diastereoselectivity in the Reduction of alpha-Oxy- and alpha-Amino-Substituted Acyclic Ketones by Polymethylhydrosiloxane", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 2, 2003, pages 594 - 596, XP003002752
NADKARNI D. ET AL.: "Diastereoselectivity in the Reduction of alpha-Oxy- and alpha-Amino-Substituted Acyclic Ketones by Polymethylhydrosiloxane", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 2, 2003, pages 594 - 596, XP003002752
Attorney, Agent or Firm:
ONDA, Hironori (Ohmiya-cho 2-chome Gifu-sh, Gifu 31, JP)
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