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Title:
BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/015634
Kind Code:
A1
Abstract:
Compositions of berberine in combination with pharmacologically active organic acids, and methods of their use in treating various diseases or disorders. Compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders. The compounds and pharmaceutical compositions can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

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Inventors:
LIU LIPING (CN)
Application Number:
PCT/CN2015/085350
Publication Date:
February 04, 2016
Filing Date:
July 28, 2015
Export Citation:
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Assignee:
SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN)
International Classes:
A61K31/4375; C07D455/03
Domestic Patent References:
WO2006029577A12006-03-23
WO2014183184A12014-11-20
WO2007005643A22007-01-11
WO2007005644A22007-01-11
WO2007016361A22007-02-08
WO2007016431A22007-02-08
Foreign References:
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CN103319479A2013-09-25
CN101113149A2008-01-30
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CN103989677A2014-08-20
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Other References:
SIQIN GAOWA. ET AL.: "The research progress of pharmacological activity of beberine from coptis", JOURNAL OF MEDICINE & PHARMACY OF CHINESE MINORITIES, no. 1, 31 January 2014 (2014-01-31), pages 49 - 51, XP008185289
P. P. BASU ET AL.: "P853 Beberine with alfa lipoic acid (ALA) in a non-alcoholic steato hepatitis (NASH), a randomized double blinded placebo control trail. A clinical pilot-the banish trial", JOURNAL OF HEPATOLOGY, vol. 60, no. 1, 1 April 2014 (2014-04-01), pages 356 - 79233
"Berberine Support / Wellness Works - Pharmacy Care", NATURALLY, 1 April 2014 (2014-04-01), Retrieved from the Internet
INDER PAL SINGH ET AL.: "Berberine and its derivatives: a patent review (2009-2012", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 23, no. 2, 12 December 2012 (2012-12-12), pages 215 - 231, XP055444683, DOI: 10.1517/13543776.2013.746314
SIQIN GAOWA ET AL.: "The research progress of pharmacological activity of berberine from coptis", JOURNAL OF MEDICINE & PHARMACY OF CHINESE MINORITIES, 31 January 2014 (2014-01-31), pages 49 - 51, XP008185289
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"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
Attorney, Agent or Firm:
ZHONGDING INTELLECTUAL PROPERTY AGENCY (Qinglin Road Longgang Distric, Shenzhen Guangdong 2, CN)
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