BETA-CATENIN TARGETING PEPTIDES AND USES THEREOF

Title:

BETA-CATENIN TARGETING PEPTIDES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2012/040459

Kind Code:

A3

Abstract:

The invention relates to β-catenin targeting peptides comprising an a-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.

More Like This:

WO/2012/161921	INTESTINAL HYPERPERMEABILITY AND PREVENTION OF SYSTEMIC DISEASE
JP7320947	A novel immunogenic CD1d-binding peptide
JP6420459	Peptide having fibrosis inhibitory activity and composition containing it

Inventors:

VERDINE GREGORY L (US)
GROSSMANN TOM N (US)
YEH TSUNG-HAN JOHANNES (US)

Application Number:

PCT/US2011/052755

Publication Date:

June 14, 2012

Filing Date:

September 22, 2011

Export Citation:

Click for automatic bibliography generation Help

Assignee:

HARVARD COLLEGE (US)
VERDINE GREGORY L (US)
GROSSMANN TOM N (US)
YEH TSUNG-HAN JOHANNES (US)

International Classes:

A61K38/10; A61K38/00

Foreign References:

US20100184645A1	2010-07-22
US7705118B2	2010-04-27

Other References:

KAWAMOTO. ET AL.: "Targeting the BCL9/B9L Binding Interaction with Beta-catenin as a Potential Anticancer Strategy. PhD Thesis.", 3 June 2010 (2010-06-03), THE UNIVERSITY OF MICHIGAN, Retrieved from the Internet [retrieved on 20120409]
XING ET AL.: "Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the beta- catenin destruction complex.", GENES DEV., vol. 17, 2003, pages 2753 - 2764

Attorney, Agent or Firm:

BAKER, C., Hunter (Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, US)

Download PDF:

View/Download PDF PDF Help

Previous Patent: INTERACTIVE CREDENTIAL SYSTEM AND METHOD

Next Patent: WET WIPES CONTAINER