Title:
BETA-HYDROXYBUTYRYL-AMINO ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/104851
Kind Code:
A3
Abstract:
Beta-hydroxybutyryl-amino acid compounds represented by formulas I, II, III, IV, V, VI, VII, VIII, IX and X, a preparation method therefor and use thereof. The compounds have antitumor activity and can be used for weight loss, anti-aging, treatment of Alzheimer's disease and epilepsy, lowering blood lipids, and lowering blood pressure.
Inventors:
LIU CHENG (CN)
ZHANG HONGYU (CN)
SUN GUANGHUI (CN)
ZHANG HONGYU (CN)
SUN GUANGHUI (CN)
Application Number:
PCT/CN2018/073231
Publication Date:
July 18, 2019
Filing Date:
January 18, 2018
Export Citation:
Assignee:
LIU CHENG (CN)
International Classes:
C07C237/22; A61K31/198; A61K31/401; A61K38/05; A61K38/06; C07K5/062; C07K5/065; C07K5/068; C07K5/072; C07K5/097; C07K5/103; C07K5/107
Foreign References:
| CN104592379A | 2015-05-06 | |||
| DE3942303A1 | 1991-06-27 | |||
| US20170296501A1 | 2017-10-19 |
Other References:
KEUL, H. ET AL.: "New Alternating Poly(Amlde-Ester)S: Synthesis and Properties", MACROMOL. SYMP., vol. 144, 31 December 1999 (1999-12-31), pages 47 - 61, XP000927406
KEUL, H. ET AL.: "New Alternating Poly(Amlde-Ester)S: Synthesis and Properties", MACROMOL SYMP., vol. 144, 31 December 1999 (1999-12-31), pages 47 - 61, XP000927406
DATABASE Registry CAS; 14 December 2007 (2007-12-14), retrieved from STN Database accession no. 958077-27-5
LAM, L.H. ET AL.: "Assay of Angiotensin I-Converting Enzyme-Inhibiting Activity Based on the Detection of 3-Hydroxybutyric Acid", ANAL. BIOCHEM., vol. 364, 22 February 2007 (2007-02-22), pages 104 - 111, XP022055850
LAM, L.H. ET AL.: "Assay of Angiotensin I-Converting Enzyme-Inhibiting Activity Based on the Detection of 3-Hydroxybutyric Acid", BIOCHEM., vol. 364, 22 February 2007 (2007-02-22), pages 104 - 111, XP022055850, doi:10.1016/j.ab.2007.02.017
SAMEL, S.A. ET AL.: "The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-Ribosomal Lipopeptide", J. MOL. BIOL, vol. 359, 18 April 2006 (2006-04-18), pages 876 - 889, XP024951101, doi:10.1016/j.jmb.2006.03.062
IRELAND , R.E. ET AL.: "3-Acyltetramic Acid Antibiotics. 3. an Approach to the Synthesis of Bu-2313", J. ORG. CHEM., vol. 52, no. 9, 31 December 1987 (1987-12-31), pages 1780 - 1789, XP055625179
KEUL, H. ET AL.: "New Alternating Poly(Amlde-Ester)S: Synthesis and Properties", MACROMOL SYMP., vol. 144, 31 December 1999 (1999-12-31), pages 47 - 61, XP000927406
DATABASE Registry CAS; 14 December 2007 (2007-12-14), retrieved from STN Database accession no. 958077-27-5
LAM, L.H. ET AL.: "Assay of Angiotensin I-Converting Enzyme-Inhibiting Activity Based on the Detection of 3-Hydroxybutyric Acid", ANAL. BIOCHEM., vol. 364, 22 February 2007 (2007-02-22), pages 104 - 111, XP022055850
LAM, L.H. ET AL.: "Assay of Angiotensin I-Converting Enzyme-Inhibiting Activity Based on the Detection of 3-Hydroxybutyric Acid", BIOCHEM., vol. 364, 22 February 2007 (2007-02-22), pages 104 - 111, XP022055850, doi:10.1016/j.ab.2007.02.017
SAMEL, S.A. ET AL.: "The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-Ribosomal Lipopeptide", J. MOL. BIOL, vol. 359, 18 April 2006 (2006-04-18), pages 876 - 889, XP024951101, doi:10.1016/j.jmb.2006.03.062
IRELAND , R.E. ET AL.: "3-Acyltetramic Acid Antibiotics. 3. an Approach to the Synthesis of Bu-2313", J. ORG. CHEM., vol. 52, no. 9, 31 December 1987 (1987-12-31), pages 1780 - 1789, XP055625179
Download PDF: