Title:
BETA-LACTAMASE SUBSTRATES HAVING PHENOLIC ETHERS
Document Type and Number:
WIPO Patent Application WO2002068678
Kind Code:
A3
Abstract:
Provided are fluorescent substrates for beta-lactamases having general formula (I), in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, --CHR2OCO(CH2)nCH3, --CHR2OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, and dislkylaminocarbonyloxymethyl, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z is a donor fluorescent moiety. Also provided are methods of use of the compound of general formula (I).
Inventors:
TSIEN ROGER Y (US)
RAO JIANGHONG (US)
RAO JIANGHONG (US)
Application Number:
PCT/US2002/000769
Publication Date:
December 04, 2003
Filing Date:
January 11, 2002
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
TSIEN ROGER Y (US)
RAO JIANGHONG (US)
TSIEN ROGER Y (US)
RAO JIANGHONG (US)
International Classes:
C07D463/00; C07D501/00; C07D501/14; C07D501/24; C07D501/28; C07D501/30; C07D501/34; C07D501/36; C07D501/40; C07D501/42; C07D501/46; C07D505/00; C07F9/6561; C12Q1/18; C12Q1/34; C12Q1/37; C12Q1/68; C12Q1/6897; (IPC1-7): C07D501/46; C07D501/24; C07D501/28; C07D501/30; C07D501/34; C07D501/36; C07D501/40; C07D501/42; C12N13/00; G01N33/573
Foreign References:
US5338843A | 1994-08-16 | |||
US5955604A | 1999-09-21 | |||
US5741657A | 1998-04-21 |
Other References:
See also references of EP 1385853A4
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