Title:
BI-FUNCTIONAL FUSION PROTEIN AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/030511
Kind Code:
A1
Abstract:
Provided is a bi-functional fusion protein that targets both TGFβ ligands and AREG, and blocks TGFβand AREG signaling simultaneously, as well as a nucleic acid molecule encoding the bi-functional fusion protein, an expression vector for producing the bi-functional fusion protein, a host cell for producing the bi-functional fusion protein, and a method for preparing and/or characterizing the bi-functional fusion protein.
Inventors:
TANG NAN (CN)
SUI JIANHUA (CN)
LIU XIMING (CN)
SONG NANMENG (CN)
ZHAO RUI (CN)
SUI JIANHUA (CN)
LIU XIMING (CN)
SONG NANMENG (CN)
ZHAO RUI (CN)
Application Number:
PCT/CN2022/116919
Publication Date:
March 09, 2023
Filing Date:
September 02, 2022
Export Citation:
Assignee:
PULMONGENE HONG KONG CO LTD (CN)
TANG NAN (CN)
TANG NAN (CN)
International Classes:
C07K19/00; A61K38/17; A61P35/00; C07K14/495; C07K14/71
Foreign References:
| US20100111965A1 | 2010-05-06 | |||
| CN110050000A | 2019-07-23 | |||
| US11028174B1 | 2021-06-08 | |||
| US20210230272A1 | 2021-07-29 | |||
| US20110150886A1 | 2011-06-23 | |||
| US20200345725A1 | 2020-11-05 |
Other References:
ROY SUYASHA, RIZVI ZAIGHAM ABBAS, CLARKE ALEXANDER J., MACDONALD FELICITY, PANDEY ABHAYDEEP, ZAISS DIETMAR MARTIN WERNER, SIMON AN: "EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093041627, DOI: 10.1038/s41467-021-23042-x
Attorney, Agent or Firm:
IPSUNNY (CN)
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