BI-SPECIFIC MONOVALENT DIABODIES THAT ARE CAPABLE OF BINDING TO GPA33 AND CD3, AND USES THEREOF

Title:

BI-SPECIFIC MONOVALENT DIABODIES THAT ARE CAPABLE OF BINDING TO GPA33 AND CD3, AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/026894

Kind Code:

A3

Abstract:

The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a "gpA33 x CD3 bi-specific monovalent diabody"). The present invention also is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc Domain ("bi- specific monovalent Fc diabodies") and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 (i.e., a "gpA33 x CD3 bi-specific monovalent Fc diabody"). The bi-specific monovalent diabodies and bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fc diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.

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Inventors:

MOORE PAUL A (US)
LI JONATHAN (US)
CHEN FRANCINE ZHIFEN (US)
JOHNSON LESLIE S (US)
SHAH KALPANA (US)
BONVINI EZIO (US)

Application Number:

PCT/US2014/051793

Publication Date:

April 16, 2015

Filing Date:

August 20, 2014

Export Citation:

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Assignee:

MACROGENICS INC (US)

International Classes:

A61K39/00; C07K16/00; C12P21/08

Domestic Patent References:

WO2012162067A2

2012-11-29

Foreign References:

US20070004909A1	2007-01-04
US20040082039A1	2004-04-29
US20030229208A1	2003-12-11
US20120184716A1	2012-07-19
US20020193571A1	2002-12-19
US20100174053A1	2010-07-08
US20100196372A1	2010-08-05
US20120289418A1	2012-11-15

Other References: