Title:
BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/008435
Kind Code:
A1
Abstract:
Disclosed is a novel biaryl amide derivative represented by formula (1) and having an affinity for the aldosterone receptor; also disclosed is a pharmaceutically acceptable salt thereof. (In the formula, A is any of the groups represented by formula (a); L is -CONH-, etc.; R1 is a substitutable aminosulfonyl group, etc; R2 is a hydrogen atom, etc.; R3 is a hydrogen atom, etc.; R4 is a hydrogen atom, a halogen atom, hydroxy group, a substitutable amino group, a substitutable C1-6 alkoxy group, a substitutable 4- to 7-membered cyclic amino group, etc.; R5a, R5b and R5c are each independently hydrogen atoms, etc.; R6 is a halogen atom, a cyano group, etc.; R7 and R8 are each independently a hydrogen atom, etc.; and m is an integer such as 0.)
Inventors:
KATAYAMA SEIJI (JP)
HORI SEIJI (JP)
HASEGAWA FUTOSHI (JP)
SUZUKI KUNIKO (JP)
HORI SEIJI (JP)
HASEGAWA FUTOSHI (JP)
SUZUKI KUNIKO (JP)
Application Number:
PCT/JP2011/065857
Publication Date:
January 19, 2012
Filing Date:
July 12, 2011
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
KATAYAMA SEIJI (JP)
HORI SEIJI (JP)
HASEGAWA FUTOSHI (JP)
SUZUKI KUNIKO (JP)
KATAYAMA SEIJI (JP)
HORI SEIJI (JP)
HASEGAWA FUTOSHI (JP)
SUZUKI KUNIKO (JP)
International Classes:
C07C311/08; A61K31/167; A61K31/18; A61K31/216; A61K31/235; A61K31/277; A61K31/341; A61K31/351; A61K31/381; A61K31/397; A61K31/40; A61K31/4015; A61K31/403; A61K31/407; A61K31/41; A61K31/415; A61K31/4164; A61K31/4196; A61K31/421; A61K31/4245; A61K31/426; A61K31/438; A61K31/439; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/444; A61K31/445; A61K31/4453; A61K31/45; A61K31/46; A61K31/495; A61K31/505; A61K31/5375; A61K31/5377; A61K31/54; A61K31/55; A61K31/553; A61P1/16; A61P3/10; A61P5/38; A61P5/42; A61P7/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P29/00; A61P43/00; C07C311/46; C07C311/54; C07C311/64; C07C317/40; C07D205/04; C07D207/06; C07D207/08; C07D207/10; C07D207/12; C07D207/27; C07D207/327; C07D207/335; C07D209/52; C07D211/22; C07D211/38; C07D211/42; C07D211/46; C07D211/62; C07D211/70; C07D211/74; C07D213/38; C07D213/40; C07D213/56; C07D213/61; C07D213/64; C07D213/74; C07D215/14; C07D231/12; C07D231/38; C07D233/56; C07D233/64; C07D233/90; C07D239/26; C07D239/42; C07D249/04; C07D249/08; C07D249/14; C07D257/04; C07D257/06; C07D263/14; C07D263/28; C07D263/32; C07D265/30; C07D267/10; C07D271/06; C07D271/10; C07D277/20; C07D277/28; C07D277/42; C07D295/08; C07D295/12; C07D295/14; C07D295/18; C07D307/14; C07D307/52; C07D307/54; C07D309/12; C07D309/14; C07D333/20; C07D333/24; C07D451/06; C07D453/02; C07D491/113
Domestic Patent References:
| WO2004110986A1 | 2004-12-23 |
Foreign References:
| JP2005507910A | 2005-03-24 | |||
| JP2009508835A | 2009-03-05 |
Other References:
ANGELL R M, ET AL.: "Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 324 - 328, XP022410909
DATABASE REGISTRY [online] 24 June 2008 (2008-06-24), XP003031838, accession no. STN Database accession no. 1030238-85-7
See also references of EP 2594554A4
DATABASE REGISTRY [online] 24 June 2008 (2008-06-24), XP003031838, accession no. STN Database accession no. 1030238-85-7
See also references of EP 2594554A4
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)
Mitsuo Tanaka (JP)
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