BIARYL DERIVATIVE AS GPR120 AGONIST

Title:

BIARYL DERIVATIVE AS GPR120 AGONIST

Document Type and Number:

WIPO Patent Application WO/2016/105118

Kind Code:

A3

Abstract:

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

Inventors:

KIM YOUNG KWAN (KR)
PARK SANG YUN (KR)
JOO HYUN WOO (KR)
CHOI EUN SIL (KR)
PAEK SEUNG YUP (KR)
KANG SEUNG WAN (KR)
KIM BYUNG GYU (KR)
LEE CHANG SEOK (KR)
KIM SUNG WOOK (KR)
LEE SANG DAE (KR)

Application Number:

PCT/KR2015/014178

Publication Date:

October 13, 2016

Filing Date:

December 23, 2015

Export Citation:

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Assignee:

LG LIFE SCIENCES LTD (KR)

International Classes:

C07D401/04; A61K31/4725; A61P3/04; A61P3/10

Domestic Patent References:

WO2011159297A1	2011-12-22
WO2013139341A1	2013-09-26
WO2013185766A1	2013-12-19
WO2014059232A2	2014-04-17
WO2014209034A1	2014-12-31

Foreign References:

KR20090113382A

2009-10-30

Other References: