Title:
BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS
Document Type and Number:
WIPO Patent Application WO/2019/045035
Kind Code:
A1
Abstract:
The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
Inventors:
KAWAMURA KIYOSHI (JP)
YAMAGISHI TATSUYA (JP)
SHISHIDO YUJI (JP)
MORITA MIKIO (JP)
YAMAGUCHI RYUICHI (JP)
OHMI MASASHI (JP)
YAMAGISHI TATSUYA (JP)
SHISHIDO YUJI (JP)
MORITA MIKIO (JP)
YAMAGUCHI RYUICHI (JP)
OHMI MASASHI (JP)
Application Number:
PCT/JP2018/032312
Publication Date:
March 07, 2019
Filing Date:
August 31, 2018
Export Citation:
Assignee:
RAQUALIA PHARMA INC (JP)
XUANZHU PHARMA CO LTD (CN)
XUANZHU PHARMA CO LTD (CN)
International Classes:
C07C311/51; A61K31/18; A61K31/397; A61K31/415; A61K31/42; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/444; A61K31/4965; A61K31/505; A61K31/506; A61K31/535; A61P29/00; C07D205/04; C07D213/64; C07D213/65; C07D213/68; C07D213/74; C07D213/82; C07D231/12; C07D239/34; C07D239/42; C07D241/18; C07D295/10; C07D401/10; C07D401/12; C07D405/12; C07D409/12; C07D417/12
Domestic Patent References:
| WO2012007868A2 | 2012-01-19 | |||
| WO2012007869A2 | 2012-01-19 | |||
| WO2013102826A1 | 2013-07-11 | |||
| WO2013088315A1 | 2013-06-20 | |||
| WO2013177224A1 | 2013-11-28 | |||
| WO2014008458A2 | 2014-01-09 | |||
| WO2010137351A1 | 2010-12-02 | |||
| WO2012053186A1 | 2012-04-26 | |||
| WO2013161308A1 | 2013-10-31 | |||
| WO2012007868A2 | 2012-01-19 | |||
| WO2012007869A2 | 2012-01-19 | |||
| WO2013088315A1 | 2013-06-20 | |||
| WO2013177224A1 | 2013-11-28 | |||
| WO2014008458A2 | 2014-01-09 | |||
| WO2015078374A1 | 2015-06-04 |
Other References:
See also references of EP 3676248A4
COX, NATURE, vol. 444, 2006, pages 894 - 898
BAKER, M.D., TRENDS IN PHARM. SCI., vol. 22, 2001, pages 27 - 31
LYU, YS., BRAIN RES., vol. 871, 2000, pages 98 - 103
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY AND SONS
J. PHARM. SCI, vol. 66, 1977, pages 1 - 19
MILLAN, PROG. NEUROBIOL., vol. 57, 1999, pages 1 - 164
WOOLFSALTER, SCIENCE, vol. 288, 2000, pages 1765 - 1768
MCCARTHY ET AL., TEXTBOOK OF PAIN, 1994, pages 387 - 395
WOOLFMANNION, LANCET, vol. 353, 1999, pages 1959 - 1964
WOOLFDECOSTERD, PAIN SUPP., vol. 6, 1999, pages S141 - S147
HOUGEMERSFELDER, ANN PHARMACOTHER., vol. 36, 2002, pages 679 - 686
FUNDAM. CLIN. PHARMACOL., vol. 25, 2011, pages 1 - 28
J. PHARM. SCI., vol. 95, 2006, pages 2115 - 2122
COX, NATURE, vol. 444, 2006, pages 894 - 898
BAKER, M.D., TRENDS IN PHARM. SCI., vol. 22, 2001, pages 27 - 31
LYU, YS., BRAIN RES., vol. 871, 2000, pages 98 - 103
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY AND SONS
J. PHARM. SCI, vol. 66, 1977, pages 1 - 19
MILLAN, PROG. NEUROBIOL., vol. 57, 1999, pages 1 - 164
WOOLFSALTER, SCIENCE, vol. 288, 2000, pages 1765 - 1768
MCCARTHY ET AL., TEXTBOOK OF PAIN, 1994, pages 387 - 395
WOOLFMANNION, LANCET, vol. 353, 1999, pages 1959 - 1964
WOOLFDECOSTERD, PAIN SUPP., vol. 6, 1999, pages S141 - S147
HOUGEMERSFELDER, ANN PHARMACOTHER., vol. 36, 2002, pages 679 - 686
FUNDAM. CLIN. PHARMACOL., vol. 25, 2011, pages 1 - 28
J. PHARM. SCI., vol. 95, 2006, pages 2115 - 2122
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Download PDF: