Title:
BIARYLOXYMETHYLARENE CARBOXYLIC ACIDS
Document Type and Number:
WIPO Patent Application WO2006058648
Kind Code:
A3
Abstract:
The present invention relates to compounds of Formula (I) wherein Ar, Ar2,R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
Inventors:
GILLESPIE PAUL (US)
GOODNOW ROBERT ALAN JR (US)
TILLEY JEFFERSON WRIGHT (US)
GOODNOW ROBERT ALAN JR (US)
TILLEY JEFFERSON WRIGHT (US)
Application Number:
PCT/EP2005/012555
Publication Date:
December 28, 2006
Filing Date:
November 24, 2005
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
GILLESPIE PAUL (US)
GOODNOW ROBERT ALAN JR (US)
TILLEY JEFFERSON WRIGHT (US)
GILLESPIE PAUL (US)
GOODNOW ROBERT ALAN JR (US)
TILLEY JEFFERSON WRIGHT (US)
International Classes:
C07D319/08; C07C65/00; C07D213/30; C07D213/61; C07D213/64; C07D213/79; C07D215/14; C07D231/12; C07D261/08; C07D277/56; C07D307/42; C07D333/16; C07D401/12; C07D409/12; C07D417/12
Domestic Patent References:
| WO2005000781A1 | 2005-01-06 | |||
| WO2004058679A2 | 2004-07-15 | |||
| WO2004067524A1 | 2004-08-12 | |||
| WO2004028634A1 | 2004-04-08 | |||
| WO1997040017A2 | 1997-10-30 | |||
| WO1993024442A1 | 1993-12-09 | |||
| WO2004071447A2 | 2004-08-26 | |||
| WO1999058518A2 | 1999-11-18 | |||
| WO2005123668A1 | 2005-12-29 | |||
| WO2003089419A1 | 2003-10-30 |
Foreign References:
| EP1452530A1 | 2004-09-01 | |||
| JPH08333287A | 1996-12-17 | |||
| EP0110299A2 | 1984-06-13 | |||
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| GB773594A | 1957-05-01 | |||
| DE2842243A1 | 1980-04-10 |
Other References:
MALAMAS M S ET AL: "Novel Benzofuran and Benzothiophene Biphenyls as Inhibitors of Protein Tyrosine Phophatase 1B with Antihyperglycemic Properties", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 7, 6 April 2000 (2000-04-06), pages 1293 - 1310, XP002190818, ISSN: 0022-2623
KARDAS D ET AL: "SYNTHESIS AND PROPERTIES OF A NEW SERIES OF MESOGENIC COMPOUNDS WITH PYRIDINE, OXIDOPYRIDINIUM, THIENYL AND FURYL MOIETIES", JOURNAL OF MATERIALS CHEMISTRY, THE ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, GB, vol. 11, no. 3, 11 January 2001 (2001-01-11), pages 741 - 748, XP009070374, ISSN: 0959-9428
KARDAS D ET AL: "SYNTHESIS AND PROPERTIES OF A NEW SERIES OF MESOGENIC COMPOUNDS WITH PYRIDINE, OXIDOPYRIDINIUM, THIENYL AND FURYL MOIETIES", JOURNAL OF MATERIALS CHEMISTRY, THE ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, GB, vol. 11, no. 3, 11 January 2001 (2001-01-11), pages 741 - 748, XP009070374, ISSN: 0959-9428
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