Title:
BIARYLUREA DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/007411
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), (wherein Ar represents a nitrogenous heterocyclic aromatic group; X and Z each represents carbon, etc.; Y represents CO, etc.; R¿1? represents hydrogen, etc.; R¿2? and R¿3? each represents hydrogen, etc.; R¿4? and R¿5? each represents hydrogen, etc.; and symbol --- represents a single bond or double bond); a process for producing the same; and a use thereof. The compounds have a remarkable proliferation-inhibitory effect on tumor cells. A Cdk4 and/or Cdk6 inhibitor for use in the therapy of malignant tumor can hence be provided.
Inventors:
HAYAMA TAKASHI (JP)
HAYASHI KYOKO (JP)
HONMA MITSUTAKA (JP)
TAKAHASHI IKUKO (JP)
HAYASHI KYOKO (JP)
HONMA MITSUTAKA (JP)
TAKAHASHI IKUKO (JP)
Application Number:
PCT/JP2000/004991
Publication Date:
February 01, 2001
Filing Date:
July 26, 2000
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
HAYAMA TAKASHI (JP)
HAYASHI KYOKO (JP)
HONMA MITSUTAKA (JP)
TAKAHASHI IKUKO (JP)
HAYAMA TAKASHI (JP)
HAYASHI KYOKO (JP)
HONMA MITSUTAKA (JP)
TAKAHASHI IKUKO (JP)
International Classes:
A61P35/00; A61P43/00; C07D213/75; C07D213/80; C07D213/81; C07D213/82; C07D231/40; C07D239/42; C07D241/20; C07D277/48; C07D277/54; C07D277/56; C07D277/82; C07D401/12; C07D409/12; C07D417/12; C07D487/04; C07D498/04; (IPC1-7): C07D213/75; A61K31/415; A61K31/4155; A61K31/426; A61K31/428; A61K31/44; A61K31/4402; A61K31/4436; A61K31/4439; A61K31/4545; A61K31/50; A61K31/505; A61K31/5383; A61K31/553; A61P35/00; A61P43/00; C07D213/81; C07D239/42; C07D239/47; C07D241/20; C07D241/40; C07D277/48; C07D277/82; C07D401/10; C07D409/12; C07D417/12; C07D487/04; C07D498/04; C07D519/00
Domestic Patent References:
| WO2000026203A1 | 2000-05-11 | |||
| WO1999065884A1 | 1999-12-23 | |||
| WO2000047577A1 | 2000-08-17 | |||
| WO1999031086A1 | 1999-06-24 | |||
| WO1999024416A1 | 1999-05-20 |
Other References:
MARCH J.: "Advanced organic chemistry", 1985, JOHN WILEY & SONS, XP002934262
PINES J.: "The cell cycle kinases", SEMIN. CANCER BIOL., vol. 5, no. 4, 1994, pages 305 - 313, XP002934263
See also references of EP 1199306A4
PINES J.: "The cell cycle kinases", SEMIN. CANCER BIOL., vol. 5, no. 4, 1994, pages 305 - 313, XP002934263
See also references of EP 1199306A4
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (2-3 Nihombashi Honcho 2-chome Chuo-ku Tokyo, JP)
BANYU PHARMACEUTICAL CO., LTD. (2-3 Nihombashi Honcho 2-chome Chuo-ku Tokyo, JP)
BANYU PHARMACEUTICAL CO., LTD. (2-3 Nihombashi Honcho 2-chome Chuo-ku Tokyo, JP)
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