BICYCLIC AMINO DERIVATIVES AND PGD2 ANTAGONIST CONTAINING THE SAME

Title:

BICYCLIC AMINO DERIVATIVES AND PGD2 ANTAGONIST CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1997/000853

Kind Code:

A1

Abstract:

Compounds of general formula (I), salts thereof or hydrates thereof wherein (a) represents (b) or (c), for example, the compounds (d) and (e), which are useful as a PGD2 antagonist and thus usable in, for example, a remedy for systemic mastocytosis or systemic mast cell activation disorders, a drug for bronchoconstriction, an antiasthmatic, a drug for allergic rhinitis agent, a drug for allergic conjunctivitis, a drug for urticaria, a remedy for ischemia reflow disorders or an antiinflammatory agent. It is particularly useful in the treatment of nasal occlusion.

Inventors:

OHTANI MITSUAKI (JP)
ARIMURA AKINORI (JP)
TSURI TATSUO (JP)
KISHINO JUNJI (JP)
HONMA TSUNETOSHI (JP)

Application Number:

PCT/JP1996/001685

Publication Date:

January 09, 1997

Filing Date:

June 19, 1996

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
OHTANI MITSUAKI (JP)
ARIMURA AKINORI (JP)
TSURI TATSUO (JP)
KISHINO JUNJI (JP)
HONMA TSUNETOSHI (JP)

International Classes:

A61K31/557; C07C233/52; C07C233/63; C07C233/74; C07C233/81; C07C233/84; C07C235/22; C07C235/36; C07C235/42; C07C235/54; C07C235/84; C07C237/38; C07C237/42; C07C245/08; C07C251/48; C07C251/86; C07C255/57; C07C271/24; C07C275/42; C07C281/14; C07C309/65; C07C311/13; C07C311/20; C07C311/29; C07C311/37; C07C311/43; C07C311/46; C07C311/51; C07C317/44; C07C323/62; C07C337/08; C07D207/34; C07D209/08; C07D209/10; C07D209/12; C07D209/42; C07D209/88; C07D213/56; C07D213/81; C07D215/36; C07D221/12; C07D235/06; C07D257/04; C07D261/18; C07D263/57; C07D271/06; C07D271/107; C07D275/03; C07D277/20; C07D277/56; C07D279/20; C07D279/22; C07D285/06; C07D285/12; C07D295/192; C07D307/68; C07D307/84; C07D307/91; C07D311/12; C07D311/24; C07D311/82; C07D313/14; C07D317/48; C07D319/24; C07D333/18; C07D333/24; C07D333/32; C07D333/34; C07D333/36; C07D333/38; C07D333/62; C07D333/68; C07D333/76; C07D333/78; C07D337/14; C07D521/00; C07F9/535; C07D263/56; C07D271/10; C07D275/02; (IPC1-7): C07C233/52; C07C233/84; C07C271/24; C07C311/06; C07C311/11; C07C311/13; C07C311/19; C07D493/08; C07D495/08; A61K31/16; A61K31/18; A61K31/27; A61K31/33; A61K31/34; A61K31/35; A61K31/38

Foreign References:

JPH06279395A	1994-10-04
JPH02180862A	1990-07-13
JPS63139161A	1988-06-10
JPS60178876A	1985-09-12

Other References: