Title:
BICYCLIC ARYL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/129473
Kind Code:
A1
Abstract:
The object is to provide a novel compound which has an S1P receptor agonist activity, can
fully act as an immunosuppressant, has few adverse side-effects, and can be administered
through the oral route. Disclosed is an S1P receptor agonist comprising a compound
represented by the general formula (I), a salt thereof, or a solvate of the compound
or the salt as an active ingredient. (I) wherein n represents 1,
2, 3 or 4; R1 represents a hydrogen atom or a C1-C6 alkyl group; R2
and R2a independently represent a hydrogen atom or a C1-C6 alkyl group,
or R2 and R2a may together form a methylene group or an ethylene
group; Ar1 represents a bivalent group derived from naphthalene,
1H-indole, 1H-pyrrolopyridine or benzofuran; and Ar2 represents
a phenyl group which may have a substituent, a thienyl group which may have a substituent,
an 1H-pyrazolyl group which may have a substituent or the like.
Inventors:
MACHINAGA NOBUO (JP)
YOSHINO TOSHIHARU (JP)
SUZUKI TAKASHI (JP)
YOSHINO TOSHIHARU (JP)
SUZUKI TAKASHI (JP)
Application Number:
PCT/JP2007/000490
Publication Date:
November 15, 2007
Filing Date:
May 09, 2007
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
MACHINAGA NOBUO (JP)
YOSHINO TOSHIHARU (JP)
SUZUKI TAKASHI (JP)
MACHINAGA NOBUO (JP)
YOSHINO TOSHIHARU (JP)
SUZUKI TAKASHI (JP)
International Classes:
C07D205/04; A61K31/397; A61K31/404; A61K31/4155; A61K31/437; A61K45/00; A61P1/04; A61P3/10; A61P5/14; A61P7/04; A61P7/06; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/04; A61P21/00; A61P21/04; A61P25/00; A61P27/02; A61P27/14; A61P29/00; A61P37/06; A61P37/08; A61P43/00; C07D403/06; C07D403/12; C07D409/12; C07D409/14; C07D471/04
Domestic Patent References:
| WO2005020882A2 | 2005-03-10 | |||
| WO2005000833A1 | 2005-01-06 | |||
| WO2006064757A1 | 2006-06-22 | |||
| WO1994008943A1 | 1994-04-28 |
Foreign References:
| JP2005515259A | 2005-05-26 |
Other References:
BRASHEAR K.M. ET AL.: "Nonpeptide glycoprotein IIB/IIIA inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 21, 1997, pages 2793 - 2798, XP002429012
MANDALA S. ET AL.: "Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists", SCIENCE, vol. 296, no. 5566, 2002, pages 346 - 349, XP001128118
BUDDE K. ET AL.: "First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients", J. AM. SOC. NEPHROL., vol. 13, no. 4, 2002, pages 1073 - 1083, XP003016978
MANDALA S. ET AL.: "Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists", SCIENCE, vol. 296, no. 5566, 2002, pages 346 - 349, XP001128118
BUDDE K. ET AL.: "First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients", J. AM. SOC. NEPHROL., vol. 13, no. 4, 2002, pages 1073 - 1083, XP003016978
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (3-6 Nihonbashiningyocho 1-chome, Chuo-k, Tokyo 13, JP)
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