Title:
BICYCLIC CINNAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2007/060821
Kind Code:
A1
Abstract:
A bicyclic cinnamide compound represented by the formula (I) [wherein (II) indicates a single bond or double bond; Ar1 represents phenyl or pyridinyl optionally substituted by one to three substituents; R1 and R2 each represents C1-6 alkyl, hydroxy, etc.; Z1 represents optionally substituted methylene or vinylene, oxygen, or imino optionally substituted by C1-6 alkyl or C1-6 acyl; and p, q, and r each is an integer of 0-2]. It functions to reduce the production of Aβ40 and Aβ42. It is hence useful especially as a preventive or remedy for neurodegenerative diseases of which Aβ is causative, such as Alzheimer's disease and Down's syndrome.
Inventors:
KIMURA TEIJI (JP)
KAWANO KOKI (JP)
DOI ERIKO (JP)
KITAZAWA NORITAKA (JP)
TAKAISHI MAMORU (JP)
ITO KOICHI (JP)
KANEKO TOSHIHIKO (JP)
SASAKI TAKEO (JP)
MIYAGAWA TAKEHIKO (JP)
HAGIWARA HIROAKI (JP)
YOSHIDA YU (JP)
KAWANO KOKI (JP)
DOI ERIKO (JP)
KITAZAWA NORITAKA (JP)
TAKAISHI MAMORU (JP)
ITO KOICHI (JP)
KANEKO TOSHIHIKO (JP)
SASAKI TAKEO (JP)
MIYAGAWA TAKEHIKO (JP)
HAGIWARA HIROAKI (JP)
YOSHIDA YU (JP)
Application Number:
PCT/JP2006/321877
Publication Date:
May 31, 2007
Filing Date:
November 01, 2006
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
KIMURA TEIJI (JP)
KAWANO KOKI (JP)
DOI ERIKO (JP)
KITAZAWA NORITAKA (JP)
TAKAISHI MAMORU (JP)
ITO KOICHI (JP)
KANEKO TOSHIHIKO (JP)
SASAKI TAKEO (JP)
MIYAGAWA TAKEHIKO (JP)
HAGIWARA HIROAKI (JP)
YOSHIDA YU (JP)
KIMURA TEIJI (JP)
KAWANO KOKI (JP)
DOI ERIKO (JP)
KITAZAWA NORITAKA (JP)
TAKAISHI MAMORU (JP)
ITO KOICHI (JP)
KANEKO TOSHIHIKO (JP)
SASAKI TAKEO (JP)
MIYAGAWA TAKEHIKO (JP)
HAGIWARA HIROAKI (JP)
YOSHIDA YU (JP)
International Classes:
C07D471/04; A61K31/4178; A61K31/437; A61K31/4375; A61K31/55; A61P25/28; C07D487/04
Domestic Patent References:
| WO2005115990A1 | 2005-12-08 | |||
| WO2005115990A1 | 2005-12-08 | |||
| WO2004002478A1 | 2004-01-08 |
Foreign References:
| JP2005531596A | 2005-10-20 | |||
| JP2004531519A | 2004-10-14 | |||
| JP2005531596A | 2005-10-20 | |||
| JP2004531519A | 2004-10-14 |
Other References:
KATO M. ET AL.: "New 5-HT3 (Serotonin-3) Receptor Antagonists. I. Synthesis and Structure-Activity Relationships of Pyrido [1,2-a]indoles", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 42, no. 12, 1994, pages 2546 - 2555, XP002162547
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 309, no. 1, April 2004 (2004-04-01), pages 49 - 55
WONG GT: "Chronic treatment with the y-secretase inhibitor LY-411,575 inhibits P-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 13, 26 March 2004 (2004-03-26), pages 12876 - 12882, XP002422797, DOI: doi:10.1074/jbc.M311652200
M. KATO ET AL., CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 42, no. 12, 1994, pages 2546 - 55
See also references of EP 1953158A4
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 309, no. 1, April 2004 (2004-04-01), pages 49 - 55
WONG GT: "Chronic treatment with the y-secretase inhibitor LY-411,575 inhibits P-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 13, 26 March 2004 (2004-03-26), pages 12876 - 12882, XP002422797, DOI: doi:10.1074/jbc.M311652200
M. KATO ET AL., CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 42, no. 12, 1994, pages 2546 - 55
See also references of EP 1953158A4
Attorney, Agent or Firm:
ASAMURA, Kiyoshi et al. (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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