BICYCLIC HETEROCYCLE DERIVATIVES HAVING SELECTIVE BACE1 INHIBITORY ACTIVITY

WIPO Patent Application WO/2019/208509

A1

The present invention provides a compound which has an effect of inhibiting amyloid β production, especially an effect of inhibiting selective BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins. A compound of the formula (IA) or the like, wherein -A1- is alkylene optionally substituted with one or more halogen; R2 is substituted or unsubstituted alkyl or the like; R3 and R4 are each independently a hydrogen atom, halogen, alkyl or haloalkyl or the like; R5 is a hydrogen atom or halogen; A4 is N or CR6 wherein R6 is a hydrogen atom, halogen, or substituted or unsubstituted alkyl; A5 is NR7 or CR8R9; A6 is CR18 or N; R18 is a hydrogen atom; R7 is substituted or unsubstituted alkyl; R8 and R9 are each independently a hydrogen atom, halogen, alkyl or haloalkyl or the like; and Ring B is bicyclic ring; or a pharmaceutically acceptable salt thereof.

WO/2016/161952	TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
WO/1993/004679	MACROCYCLIC IMMUNOMODULATORS
JPH09512559	Manufacture of the camptothecin derivative according to cyclization in a molecule

UENO TATSUHIKO (JP)
FUCHINO KOUKI (JP)
FUJIMOTO KAZUKI (JP)
ROMBOUTS FREDERIK (BE)
VAN DEN BOSSCHE DRIES (BE)
SURKYN MICHEL (BE)
DE CLEYN MICHEL (BE)

PCT/JP2019/017054

October 31, 2019

April 22, 2019

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SHIONOGI & CO (JP)
JANSSEN PHARMACEUTICA NV (BE)

C07D491/056; A61K31/542; A61K31/549; A61P25/28; C07D519/00

WO2011044181A1	2011-04-14
WO2017050978A1	2017-03-30

US20140235626A1	2014-08-21
US20140107109A1	2014-04-17
US20150038497A1	2015-02-05
JP2012250933A	2012-12-20

SUGITA Ken-ichi et al. (JP)

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