Title:
BICYCLIC HETEROCYCLIC COMPOUNDS AS PDE2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2017/000276
Kind Code:
A1
Abstract:
The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
Inventors:
SATCHEL SHAWN J (US)
SINZ CHRISTOPHER J (US)
CHEN YILI (US)
WILSON JONATHAN E (US)
DWYER MICHAEL (US)
PAONE DANIEL V (US)
XU SHIMIN (CN)
SINZ CHRISTOPHER J (US)
CHEN YILI (US)
WILSON JONATHAN E (US)
DWYER MICHAEL (US)
PAONE DANIEL V (US)
XU SHIMIN (CN)
Application Number:
PCT/CN2015/083059
Publication Date:
January 05, 2017
Filing Date:
July 01, 2015
Export Citation:
Assignee:
MERCK SHARP & DOHME (US)
SATCHEL SHAWN J (US)
SINZ CHRISTOPHER J (US)
CHEN YILI (US)
WILSON JONATHAN E (US)
DWYER MICHAEL (US)
PAONE DANIEL V (US)
XU SHIMIN (CN)
SATCHEL SHAWN J (US)
SINZ CHRISTOPHER J (US)
CHEN YILI (US)
WILSON JONATHAN E (US)
DWYER MICHAEL (US)
PAONE DANIEL V (US)
XU SHIMIN (CN)
International Classes:
C07D487/04; A61K31/519; A61K31/537; C07D487/00; C07D487/02; A61K31/5395; A61P25/16; A61P25/18; A61P25/22; A61P25/24; C07D487/10
Domestic Patent References:
| WO2014024125A1 | 2014-02-13 | |||
| WO2013110768A1 | 2013-08-01 |
Foreign References:
| US3840537A | 1974-10-08 |
Attorney, Agent or Firm:
WU, FENG & ZHANG CO. (CN)
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