Title:
BICYCLIC HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2017/209265
Kind Code:
A1
Abstract:
Provided are: a novel compound having P2X7 receptor inhibitory activity; and a pharmaceutical composition having P2X7 receptor inhibitory activity.
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
(In the formula, Z1 represents C(R4) or N; R4 represents a hydrogen atom or the like; each of Z2 and Z3 independently represents a carbon atom or a nitrogen atom; the broken line represents the presence or absence of a bond; ring Q represents a six-membered aromatic carbon ring or the like; each R5 independently represents a halogen atom or the like; Y1 represents O or the like; R1 represents a substituted or unsubstituted aromatic carbocyclic group or the like; each of R2a and R2b independently represents a hydrogen atom or the like; X represents N(R7a) or the like; R7a represents a hydrogen atom or the like; R3 represents a group represented by formula A or the like; ring B represents a six-membered aromatic carbon ring or the like; each of R9a and R10a independently represents a halogen atom or the like; n represents an integer of 1-5; m represents an integer of 0-4; p1 represents an integer of 0-3; and s represents an integer of 0-4.)
Inventors:
ICHIHASHI YUSUKE (JP)
KUDO HIROMI (JP)
KOBAYASHI NAOTAKE (JP)
KUROSE NORIYUKI (JP)
NAKAHASHI ATSUFUMI (JP)
KUDO HIROMI (JP)
KOBAYASHI NAOTAKE (JP)
KUROSE NORIYUKI (JP)
NAKAHASHI ATSUFUMI (JP)
Application Number:
PCT/JP2017/020532
Publication Date:
December 07, 2017
Filing Date:
June 02, 2017
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D239/70; A61K31/517; A61K31/519; A61K31/522; A61P19/02; A61P25/04; A61P25/28; A61P29/00; A61P37/02; A61P43/00; C07D417/12; C07D473/18; C07D475/04; C07D491/048
Domestic Patent References:
| WO2016088838A1 | 2016-06-09 | |||
| WO2015065336A1 | 2015-05-07 | |||
| WO2015099107A1 | 2015-07-02 | |||
| WO2006003500A1 | 2006-01-12 | |||
| WO2011012592A1 | 2011-02-03 | |||
| WO2010126104A1 | 2010-11-04 | |||
| WO2011079000A1 | 2011-06-30 |
Foreign References:
| JP2012527471A | 2012-11-08 | |||
| EP2725024A1 | 2014-04-30 |
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
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