Title:
BICYCLIC INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3
Document Type and Number:
WIPO Patent Application WO2001044246
Kind Code:
A8
Abstract:
Bicyclic based compounds of the formula (I), compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and a treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
Inventors:
NUSS JOHN M (US)
ZHOU XIAOHUI A (US)
ZHOU XIAOHUI A (US)
Application Number:
PCT/US2000/034049
Publication Date:
October 25, 2001
Filing Date:
December 14, 2000
Export Citation:
Assignee:
CHIRON CORP (US)
NUSS JOHN M (US)
ZHOU XIAOHUI A (US)
NUSS JOHN M (US)
ZHOU XIAOHUI A (US)
International Classes:
A61K31/519; A61K45/00; A61P3/04; A61P3/10; A61P9/10; A61P9/12; C12N9/99; A61P15/00; A61P17/02; A61P25/28; A61P35/00; A61P37/00; A61P43/00; C07D471/04; C12N5/07; C12N5/078; C12N5/09; (IPC1-7): C07D471/04; A61K31/519; A61P3/10
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