Title:
BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING VIRUS GROWTH INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2023/033098
Kind Code:
A1
Abstract:
The present invention provides a compound that exhibits an inhibitory activity against coronavirus 3CL protease or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same. A compound represented by formula (I) (in the formula; X represents -NH-, etc.; Y represents =N-, etc.; Z represents -NR1-, etc.; W represents =N-, etc.; R1 represents a substituted alkyl, a substituted or unsubstituted aromatic heterocyclic group, etc.; R2a represents a substituted or unsubstituted aromatic carbon cyclic group, etc.; R2b represents a hydrogen atom, etc.; n represents 1, etc.; R4a represents a hydrogen atom, a substituted or unsubstituted alkyl, etc.; and R4b represents a hydrogen atom, etc.), or a pharmaceutically acceptable salt thereof.
Inventors:
UNOH YUTO (JP)
YOSHIDA SHUHEI (JP)
NAKAHARA KENJI (JP)
KOJIMA EIICHI (JP)
SASAKI YOSHIKAZU (JP)
MIYAGAWA MASAYOSHI (JP)
YOSHIDA SHUHEI (JP)
NAKAHARA KENJI (JP)
KOJIMA EIICHI (JP)
SASAKI YOSHIKAZU (JP)
MIYAGAWA MASAYOSHI (JP)
Application Number:
PCT/JP2022/032906
Publication Date:
March 09, 2023
Filing Date:
September 01, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07D487/04; A61K31/53; A61P31/14; A61P43/00; C07D491/20
Domestic Patent References:
| WO2018074390A1 | 2018-04-26 | |||
| WO2022138987A1 | 2022-06-30 |
Foreign References:
| JP2019182806A | 2019-10-24 | |||
| JP2019182865A | 2019-10-24 | |||
| JP7105430B1 | 2022-07-25 | |||
| JP2022537595A | 2022-08-26 | |||
| JP2022108241A | 2022-07-25 |
Other References:
LIU YUZHI; LIANG CHENGYUAN; XIN LIANG; REN XIAODONG; TIAN LEI; JU XINGKE; LI HAN; WANG YONGBO; ZHAO QIANQIAN; LIU HONG; CAO WENQIA: "The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 206, 6 August 2020 (2020-08-06), AMSTERDAM, NL , XP086299093, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112711
OLUBIYI OLUJIDE O., OLAGUNJU MARYAM, KEUTMANN MONIKA, LOSCHWITZ JENNIFER, STRODEL BIRGIT: "High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2", MOLECULES, vol. 25, no. 14, pages 3193, XP055944494, DOI: 10.3390/molecules25143193
AKAJI KENICHI, KONNO HIROYUKI: "Design and Evaluation of Anti-SARS-Coronavirus Agents Based on Molecular Interactions with the Viral Protease", MOLECULES, vol. 25, no. 17, pages 3920, XP055826867, DOI: 10.3390/molecules25173920
OLUBIYI OLUJIDE O., OLAGUNJU MARYAM, KEUTMANN MONIKA, LOSCHWITZ JENNIFER, STRODEL BIRGIT: "High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2", MOLECULES, vol. 25, no. 14, pages 3193, XP055944494, DOI: 10.3390/molecules25143193
AKAJI KENICHI, KONNO HIROYUKI: "Design and Evaluation of Anti-SARS-Coronavirus Agents Based on Molecular Interactions with the Viral Protease", MOLECULES, vol. 25, no. 17, pages 3920, XP055826867, DOI: 10.3390/molecules25173920
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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