Title:
BICYCLIC NUCLEOCAPSID INHIBITOR AND USE OF SAME AS DRUG IN TREATMENT OF HEPATITIS B
Document Type and Number:
WIPO Patent Application WO/2018/202155
Kind Code:
A1
Abstract:
The present invention relates to a bicyclic nucleocapsid inhibitor and the use of the same as a drug in the treatment of hepatitis B. In particular, disclosed is a compound having the structure as shown in chemical formula A, or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt, a hydrate or a solvate thereof that can be used as an HBV inhibitor, wherein the definition of each group is as described in detail in the description. The present invention also relates to a pharmaceutical composition comprising the compound and the use of the same in the treatment of hepatitis B.
Inventors:
WANG ZHE (CN)
FAN GUOQIN (CN)
LU CENBIN (CN)
YANG SAI (CN)
WANG XIAOGUANG (CN)
FAN GUOQIN (CN)
LU CENBIN (CN)
YANG SAI (CN)
WANG XIAOGUANG (CN)
Application Number:
PCT/CN2018/085695
Publication Date:
November 08, 2018
Filing Date:
May 04, 2018
Export Citation:
Assignee:
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07D487/04
Domestic Patent References:
| WO2013006394A1 | 2013-01-10 | |||
| WO2013096744A1 | 2013-06-27 |
Foreign References:
| CN103224466A | 2013-07-31 | |||
| CN101001856A | 2007-07-18 | |||
| US4208210A | 1980-06-17 | |||
| US4334004A | 1982-06-08 |
Other References:
KLEYMANN, GERALD ET AL.: "A generally applicable, high-throughput screening-compatible assay to identify, evaluate, and optimize antimicrobial agents for drug therapy", JOURNAL OF BIOMOLECULAR SCREENING, vol. 9, no. 7, 9 February 2004 (2004-02-09), pages 578 - 587, XP002567618
See also references of EP 3628674A4
See also references of EP 3628674A4
Attorney, Agent or Firm:
XU AND PARTNERS, LLC. (CN)
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